FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\perTag:HA,Tag:polyHis
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General Information
Symbol
Dmel\perTag:HA,Tag:polyHis
Species
D. melanogaster
Name
FlyBase ID
FBal0264203
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{per13.2.HA10His}
P{per(13.2WT)-HA-10HIS}
Also Known As
p{dper(WT)}, 13.2(per+-HA10His), 13.2per+-HAHis, p{dper}, per+-HAHis
Key Links
Transgenic product class
genomic_DNA
(Lee et al., 1998)
wild_type
(Lee et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Lee et al., 1998)
wild_type
(Lee et al., 1998)
Mutagen
in vitro construct
(Chiu et al., 2011, Lee et al., 1998)
Progenitor genotype
per+t13.2
(Lee et al., 1998)
Carried in construct
P{per13.2.HA10His}
P{per(13.2WT)-HA-10HIS}
Cytology
Description

Contains a 13.2kb per genomic fragment tagged with an Tag:HA epitope tag and Tag:polyHis at the carboxyl-terminus.

(Chiu et al., 2011)

A Tag:HA tag followed by a stretch of 10 His residues have been inserted just upstream of the per stop codon.

(Lee et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
per
Encoded product / tool
per
Tagged with
Tag:HA
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In a homozygous per01 genetic background, perT:Ivir\HA1.T:Zzzz\His6 transgenic flies exhibit strong circadian locomotory rhythms with approximately 24 hour periods.

      (Chiu et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The aberrant long-period circadian locomotor rhythm under free-running constant dark conditions characteristic for Lsm12Δ3 or Lsm12Δ6 mutant adults is partially rescued by combination with a single copy of perT:Ivir\HA1,T:Zzzz\His6.

      (Lee et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      perTag:HA,Tag:polyHis rescues per01

      (Kang et al., 2025)
      Comments

      per01 adults expressing perS942A.Tag:HA,Tag:polyHis and fed with [15]N exhibit strong behavioral rhythms with periods close to 24 hours in constant darkness (DD) as per01 adults expressing perS942A.Tag:HA,Tag:polyHis and fed with [14]N (controls).

      Expression of perTag:HA,Tag:polyHis/+ rescues the arrhythmic locomotor behavior of per01 adults while expression of perTag:HA,Tag:polyHis/perTag:HA,Tag:polyHis in per01 background leads to shorter locomotor behavioral rhythms under constant dark condition (DD) compared to controls.

      Expression of perTag:HA,Tag:polyHis rescues the arrhythmic feeding behavior of per01 adults in both LD (light-dark cycle) and DD.

      (Li et al., 2019)

      per01 flies carrying perT:Ivir\HA1,T:Zzzz\His6 have robust locomotor activity rhythms with 23.5 hour periods when the free running period is determined in constant darkness conditions at 25[o]C after 4 days of 12 hour light: 12 hour dark conditions. The activity rhythm period of 23.5 hours is stable over a wide range of temperatures tested (18[o], 25[o] and 29[o]C) in these flies.

      (Sun et al., 2010)

      perT:Ivir\HA1,T:Zzzz\His6, per01 flies manifest robust locomotor activity rhythms with periods similar to controls.

      (Kim et al., 2007)

      perT:Ivir\HA1,T:Zzzz\His6 rescues the arrhythmicity seen in per01 flies under constant darkness conditions and the rescued flies have a normal period length (rescues is seen at 18, 25 and 29[o]C). The rescued flies also show normal locomotor activity rhythms under 12 hour light: 12 hour dark conditions.

      (Ko et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      perT:Ivir\HA1,T:Zzzz\His6
      perT:Ivir\HA1.T:Zzzz\His6
      perTag:HA,Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (15)