FlyBase Allele Report: Dmel\sog[u.UAS]

General Information

Symbol

Dmel\sog^u.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0264208

Feature type

allele

Associated gene

Dmel\sog

Associated Insertion(s)

Carried in Construct

P{UAS-sog.u}

Key Links

Transgenic product class

missense_variant

(Peluso et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Peluso et al., 2011)

Mutagen

in vitro construct

(Peluso et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-sog.u}

Cytology

Description

UAS regulatory sequences drive expression of sog with mutated proteolytic processing sites 1 and 2 (V[183]ALD and V[728]PGD, respectively).

(Peluso et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

sog

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^A9

(Peluso et al., 2011)

Phenotype Manifest In

posterior crossvein, with Scer\GAL4^A9

(Peluso et al., 2011)

Detailed Description

Statement

Reference

Overexpression of sog^u.Scer\UAS in the wing disc under the control of Scer\GAL4^A9 produces a significant loss of posterior crossvein.

(Peluso et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^A9, sog^u.UAS has visible phenotype, enhanceable by Scer\GAL4^A9/tok^{UAS.cSa.Tag:HA}

(Peluso et al., 2011)

Other

Statement

Reference

Scer\GAL4^A9, sog^u.UAS, tok^{UAS.cSa.Tag:HA}, tsg^UAS.cYa has visible phenotype

(Peluso et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^A9, sog^u.UAS has posterior crossvein phenotype, enhanceable by Scer\GAL4^A9/tok^{UAS.cSa.Tag:HA}

(Peluso et al., 2011)

Other

Statement

Reference

Scer\GAL4^A9, sog^u.UAS, tok^{UAS.cSa.Tag:HA}, tsg^UAS.cYa has wing vein phenotype

(Peluso et al., 2011)

Scer\GAL4^A9, sog^u.UAS, tok^{UAS.cSa.Tag:HA}, tsg^UAS.cYa has wing blade phenotype

(Peluso et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of the posterior crossvein due to sog^u.Scer\UAS-overexpression is exacerbated when tok^{Scer\UAS.cSa.T:Ivir\HA1} is also expressed under the control of Scer\GAL4^A9.

Co-overexpression of tok^{Scer\UAS.cSa.T:Ivir\HA1} with sog^u.Scer\UAS and tsg^Scer\UAS.cYa under the control of Scer\GAL4^A9 results in a small-wing phenotype and abnormal wing vein patterning.

(Peluso et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sog^u.Scer\UAS

sog^u.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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