FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nwkSH3ab.UAS
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General Information
Symbol
Dmel\nwkSH3ab.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264540
Feature type
allele
Associated gene
Dmel\nwk
Associated Insertion(s)
Carried in Construct
P{UAS-nwk.SH3ab}
Key Links
Transgenic product class
missense_variant
(Rodal et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Rodal et al., 2008)
Mutagen
in vitro construct
(Rodal et al., 2008)
Progenitor genotype
nwkUAS.cCa
(Rodal et al., 2008)
Carried in construct
P{UAS-nwk.SH3ab}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of nwk in which the tryptophans at residues 531 and 677 has been replaced by alanine.

(Rodal et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
nwk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of nwkSH3ab.Scer\UAS under the control of Scer\GAL4elav-C155 results in synaptic overgrowth and an increase in bouton number in segment A3, muscle 6/7 in third instar larvae.

      (Rodal et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      nwkSH3ab.UAS fails to rescue nwk1/nwk2

      (Rodal et al., 2008)
      Comments

      Expression of nwkSH3ab.Scer\UAS under the control of Scer\GAL4elav-C155 enhances the synaptic overgrowth and increased bouton number phenotypes seen in nwk1/nwk2 third instar larvae.

      (Rodal et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nwkSH3ab.Scer\UAS
      nwkSH3ab.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)