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General Information
Symbol
Dmel\PGRP-LCI.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0264785
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
PGRP-LC-I
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a truncated form of PGRP-LC (amino acids 1-323) that lacks the extracellular domain but retains the membrane spanning intracellular fragment common to all isoforms.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of PGRP-LCI.Scer\UAS.T:Zzzz\FLAG under the control of either Scer\GAL4Cg.PA, Scer\GAL4Hml.PG or Scer\GAL4yolk results in induction of IMD pathway activation in the absence of bacterial infection.

Expression of PGRP-LCI.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Cg.PA results in spontaneous and massive melanization in larval, pupal and adult tissues in the absence of bacterial infection. A less severe phenotype is seen under the control of Scer\GAL4Hml.PG, and no melanization is seen when PGRP-LCI.Scer\UAS.T:Zzzz\FLAG is expressed under the control of Scer\GAL4yolk.

Expression of PGRP-LCI.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Cg.PA results in severe developmental delays (>10-15 days). Larvae and pupae with severe melanization do not survive to adulthood.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
PGRP-LCI.Scer\UAS.T:Zzzz\FLAG
PGRP-LCI.UAS.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (2)