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General Information
Symbol
Dmel\Hipkw.D1
Species
D. melanogaster
Name
FlyBase ID
FBal0264886
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

FLP-mediated transposition of PBac{WH}Hipkf03158 and P{XP}Hipkd10792 generates a deletion that removes ~92% of the Hipk coding region by replacing residues 1-1243 with the w+ marker gene.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

FLP-mediated transposition of PBac{WH}hipkf03158 and P{XP}hipkd10792 generates a deletion that removes ~92% of the hipk coding region by replacing residues 1-1243 with the w+ marker gene.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wings mosaic for hipkw.D1 are normal at eclosion, but upon aging show severe blemishing and persisting cell phenotypes.

hipkw.D1 mutants are lethal before the 3rd instar stage. Approximately 70% of hipkw.D1 homozygotes hatch to 1st instar larvae.

Zygotic hipkw.D1 animals possess cell numbers equivalent to wild-type, but maternal hipkw.D1 embryos have supernumerary cells comparable to levels seem in apoptosis-deficient embryos (i.e. Df(3L)H99 embryos). hipkw.D1 mutants show extra exex-positive cells and altered CNS patterning. hipkw.D1 mutant pupal eyes exhibit more interommatidial cells, indicative of a defect in cell death. Distorted patterning of ommatidia and abnormal numbers of primary pigment cells are also seen in a subset of animals.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Hipkw.D1
hipkw.D1
Name Synonyms
Secondary FlyBase IDs
    References (1)