FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Smg6292
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General Information
Symbol
Dmel\Smg6292
Species
D. melanogaster
Name
FlyBase ID
FBal0265374
Feature type
allele
Associated gene
Dmel\Smg6
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Frizzell et al., 2012)
Mutagen
ethyl methanesulfonate
(Frizzell et al., 2012)
Progenitor genotype
Cytology
Description

Point mutation (GT to AT) disrupting the sixth intron splice site. This results in the protein being truncated at amino acid 558.

(Long et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:25,031,358..25,031,358 [-]
Nucleotide change:

G25031358A

Comment:

A point mutation (GT to AT) disrupts the sixth intron splice donor site and truncates the Smg6 protein after amino acid 558.

(Frizzell et al., 2012, Long et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Smg6292 mutant cells are defective in cell proliferation when in competition with wild type cells, as assayed by examination of mitotic clones within the eye. However no proliferation defects are seen when eyes are completely mutant for Smg6292.

      (Frizzell et al., 2012)

      Smg6292 mutants exhibit a mean EJC amplitude of 41.3nA compared to 75.2nA in controls.

      Application of FM1-43 dye after a 20Hz, 1 minute stimulation reveals a reduction in dye uptake in Smg6292 mutants.

      (Long et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Df(3R)ED6220/Smg6292 has partially lethal - majority live phenotype, non-enhanceable by nonC32AP/nonC32AP

      (Nelson et al., 2018)
      NOT suppressed by
      Statement
      Reference

      Df(3R)ED6220/Smg6292 has partially lethal - majority live phenotype, non-suppressible by nonC32AP/nonC32AP

      (Nelson et al., 2018)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      292
      (Frizzell et al., 2012)
      Smg6292
      (Nelson et al., 2018, Frizzell et al., 2012, Long et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)