FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MadNIG.12399R
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General Information
Symbol
Dmel\MadNIG.12399R
Species
D. melanogaster
Name
FlyBase ID
FBal0265674
Feature type
allele
Associated gene
Dmel\Mad
Associated Insertion(s)
Carried in Construct
P{NIG.12399R}
Also Known As
UAS-Mad-i
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Umemori et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Umemori et al., 2009)
Mutagen
in vitro construct
(Umemori et al., 2009)
Progenitor genotype
Carried in construct
P{NIG.12399R}
Cytology
Description

UASt regulatory sequences drive expression of an RNAi construct targeting Mad.

(Umemori et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-12399R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of MadNIG.12399R under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi) leads to mis-patterned wings of abnormal size, as compared to controls.

      (Hevia et al., 2017)

      Expression of Scer\GAL4ap-md544 under the control of Scer\GAL4ap-md544 induces non-cell autonomous apoptosis in the wing imaginal discs.

      (Umemori et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      MadNIG.12399R, Scer\GAL4nub.PU is a suppressor of wing phenotype of Scer\GAL4nub.PU, SmoxSDVD.UAS

      (Hevia et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of MadNIG.12399R (together with Dicer-2, for efficient RNAi) suppresses the oversized wing defects induced by the expression of SmoxSDVD.Scer\UAS under the control of Scer\GAL4nub.PU.

      (Hevia et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MadNIG.12399R
      Name Synonyms
      Secondary FlyBase IDs
        References (9)