FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pex16UAS.cNa
Open Close
General Information
Symbol
Dmel\Pex16UAS.cNa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Nakayama
FlyBase ID
FBal0265695
Feature type
allele
Associated gene
Dmel\Pex16
Associated Insertion(s)
Carried in Construct
P{UAS-pex16.N}
Key Links
Transgenic product class
wild_type
(Nakayama et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Nakayama et al., 2011)
Mutagen
in vitro construct
(Nakayama et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-pex16.N}
Cytology
Description

UAS regulatory sequences drive expression of the Pex16 coding region (intron sequences have been removed).

(Nakayama et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pex16
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Pex16Scer\UAS.cNa under the control of Scer\GAL4NP5021 results in Malpighian tubule cells containing fewer and larger peroxisomes compared to controls.

      Expression of Pex16Scer\UAS.cNa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in spermatocytes containing fewer and larger peroxisomes compared to controls.

      (Nakayama et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Pex16UAS.cNa, Scer\GAL4elav.PU, Scer\GAL4Lsp2.PH rescues Pex161

      (Nakayama et al., 2011)

      Pex16UAS.cNa/Scer\GAL4ptc-559.1 rescues Pex161

      (Nakayama et al., 2011)
      Partially rescues

      Pex16UAS.cNa/Scer\GAL4elav.PU partially rescues Pex161

      (Nakayama et al., 2011)

      Pex16UAS.cNa/Scer\GAL4Lsp2.PH partially rescues Pex161

      (Nakayama et al., 2011)
      Fails to rescue

      Pex16UAS.cNa/Scer\GAL4NP5021 fails to rescue Pex161

      (Nakayama et al., 2011)

      Pex16UAS.cNa/Scer\GAL4VP16.nanos.UTR fails to rescue Pex161

      (Nakayama et al., 2011)
      Comments

      Expression of Pex16Scer\UAS.cNa under the simultaneous control of Scer\GAL4elav.PU and Scer\GAL4Lsp2.PH rescues the shortened lifespan, climbing defects and flight ability defects that are seen in Pex161 homozygotes. Expression under the control of either driver alone does not rescue these defects.

      Expression of Pex16Scer\UAS.cNa under the control of either Scer\GAL4elav.PU or Scer\GAL4Lsp2.PH rescues the defects in the dendritic trees of the lobula plate which are seen in Pex161 homozygotes.

      Expression of Pex16Scer\UAS.cNa under the control of Scer\GAL4NP5021 does not rescue the shortened lifespan, climbing defects and flight ability defects that are seen in Pex161 homozygotes.

      Expression of Pex16Scer\UAS.cNa under the control of Scer\GAL4ptc-559.1 (in the cyst cells of the testis) rescues the fertility of Pex161 males: morphologically normal spermatids and moving sperm are seen in these flies. Expression of Pex16Scer\UAS.cNa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 (in the germline cells) does not rescue the sterility or defective spermatogenesis of Pex161 males.

      (Nakayama et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Pex16Scer\UAS.cNa
      Pex16UAS.cNa
      pex16Scer\UAS.cNa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Nakayama
      Secondary FlyBase IDs
        References (1)