FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mkk4G343
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General Information
Symbol
Dmel\Mkk4G343
Species
D. melanogaster
Name
FlyBase ID
FBal0265735
Feature type
allele
Associated gene
Dmel\Mkk4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Geuking et al., 2009)
Progenitor genotype
Cytology
Description

A G to A nucleotide change results in replacement of the valine at amino acid 250 with a methionine.

(Geuking et al., 2009)

Amino acid replacement: V250M.

(Geuking et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,649,603..8,649,603 [-]
Nucleotide change:

G8649603A

Reported nucleotide change:

G?A

Amino acid change:

V250M | Mkk4-PA; V250M | Mkk4-PB; V250M | Mkk4-PC

Reported amino acid change:

V250M

Comment:

GTG to ATG substitution reported.

(Geuking et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mkk4G343/Df(3R)Exel6149 flies are viable and do not show any obvious morphological defects.

      (Geuking et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Mkk4G343/Mkk4[+] is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)

      Mkk4G343/Mkk4[+] is a suppressor of visible | adult stage phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Mkk4G343/Mkk4[+] is a suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mkk4G343/+ suppresses the small eye phenotype seen when egrScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PF.

      (Geuking et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mkk4G343
      (Geuking et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)