FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mkk4G680
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General Information
Symbol
Dmel\Mkk4G680
Species
D. melanogaster
Name
FlyBase ID
FBal0265747
Feature type
allele
Associated gene
Dmel\Mkk4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Geuking et al., 2009)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q341term.

(Geuking et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,649,041..8,649,041 [-]
Nucleotide change:

C8649041T

Reported nucleotide change:

C?T

Amino acid change:

Q341term | Mkk4-PA; Q341term | Mkk4-PB; Q341term | Mkk4-PC

Reported amino acid change:

Q341term

Comment:

CAA to TAA substitution reported.

(Geuking et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mkk4G680/Df(3R)Exel6149 flies are viable and do not show any obvious morphological defects.

      (Geuking et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT suppressed by
      Statement
      Reference

      Mkk4[+]/Mkk4G680, Scer\GAL4GMR.PF, egrUAS.cMa has abnormal size | adult stage phenotype, non-suppressible by Df(3R)Exel6149/+

      (Geuking et al., 2009)

      Mkk4[+]/Mkk4G680, Scer\GAL4GMR.PF, egrUAS.cMa has visible | adult stage phenotype, non-suppressible by Df(3R)Exel6149/+

      (Geuking et al., 2009)
      Suppressor of
      Statement
      Reference

      Mkk4[+]/Mkk4G680 is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)

      Mkk4[+]/Mkk4G680 is a suppressor of visible | adult stage phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Mkk4[+]/Mkk4G680, Scer\GAL4GMR.PF, egrUAS.cMa has eye phenotype, enhanceable by Mkk4tub.cGa, Scer\GAL4GMR.PF

      (Geuking et al., 2009)
      NOT suppressed by
      Statement
      Reference

      Mkk4[+]/Mkk4G680, Scer\GAL4GMR.PF, egrUAS.cMa has eye phenotype, non-suppressible by Df(3R)Exel6149/+

      (Geuking et al., 2009)
      Suppressor of
      Statement
      Reference

      Mkk4[+]/Mkk4G680 is a suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mkk4G680/+ suppresses the small eye phenotype seen when egrScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PF.

      One copy of Df(3R)Exel6149 is unable to suppress the phenotype seen when egrScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PF with one copy of Mkk4G680.

      Co-expression of Mkk4tub.cGa reverts the suppressive effect of Mkk4G680 on the small eye phenotype seen when egrScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PF.

      (Geuking et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mkk4G680
      (Geuking et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)