FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GlcAT-Pbrv3
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General Information
Symbol
Dmel\GlcAT-Pbrv3
Species
D. melanogaster
Name
brave3
FlyBase ID
FBal0265807
Feature type
allele
Associated gene
Dmel\GlcAT-P
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pandey et al., 2011)
Progenitor genotype
Cytology
Description

A T to A transversion has occurred in the 27th position of the 8th (last) exon, resulting in a non-synonymous Leu to Gln polymorphism.

(Pandey et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:11,178,452..11,178,452 [-]
Nucleotide change:

T11178452A

Reported nucleotide change:

T?A

Amino acid change:

L469Q | GlcAT-P-PA; L306Q | GlcAT-P-PB; L306Q | GlcAT-P-PC; L469Q | GlcAT-P-PD; L306Q | GlcAT-P-PE

Reported amino acid change:

L?Q

Comment:

Leu to Gln change in the 27th codon of the final exon. See also Figure S1.

(Pandey et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GlcAT-Pbrv3 mutant 3rd instar larvae exhibit a dramatically extended larval ventral nerve cord, 2-3 times that found in wild-type controls.

      GlcAT-Pbrv3 adult escapers show developmental defects in the legs, while some exhibit rudimentary wings.

      (Pandey et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      GlcAT-Pbrv3 is rescued by GlcAT-PCH322-82E19

      (Pandey et al., 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GlcAT-Pbrv3
      brv3
      (Pandey et al., 2011)
      Name Synonyms
      brave3
      (Pandey et al., 2011)
      Secondary FlyBase IDs
        References (1)