FB2021_02, released April 13, 2021

Allele: Dmel\Gr64eUAS.cWa

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General Information
Symbol
Dmel\Gr64eUAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0265813
Feature type
allele
Associated gene
Dmel\Gr64e
Associated Insertion(s)
Carried in Construct
P{UAS-Gr64e.W}
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Wisotsky et al., 2011)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-Gr64e.W}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of Gr64e coding sequences.

      (Wisotsky et al., 2011)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      Gr64e
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Gr64eScer\UAS.cWa via Scer\GAL4Gr5a.8.5 does not affect glycerol sensitivity.

      Ectopic expression of Gr64eScer\UAS.cWa in the ab1C neuron (under the control of Scer\GAL4Gr21a.9.323 and Scer\GAL4Gr63a.PF) confers glycerol sensitivity in a dose-dependent manner. This expression also causes a small elevation in the spontaneous firing rate of the ab1C neuron but does not alter the response to CO[[2]].

      Ectopic expression of Gr64eScer\UAS.cWa in the ab1C neuron (under the control of Scer\GAL4Gr21a.9.323 and Scer\GAL4Gr63a.PF) confers 1,2-propanediol sensitivity, but does not confer sensitivity to sucrose, glucose or fructose.

      (Wisotsky et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Gr64eUAS.cWa/Scer\GAL4Gr5a.8.5 rescues Gr64eMB03533

      (Wisotsky et al., 2011)
      Comments

      Expression of Gr64eScer\UAS.cWa in sugar taste neurons (under the control of Scer\GAL4Gr5a.8.5) restores glycerol sensitivity.

      (Wisotsky et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gr64eScer\UAS.cWa
      Gr64eUAS.cWa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)