FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Inx2FA42
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General Information
Symbol
Dmel\Inx2FA42
Species
D. melanogaster
Name
FlyBase ID
FBal0265867
Feature type
allele
Associated gene
Dmel\Inx2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Mukai et al., 2011)
Mutagen
ethyl methanesulfonate
(Mukai et al., 2011)
Progenitor genotype
Cytology
Description

12bp deletion within the intron.

(Mukai et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:7,000,848..7,000,859 [+]
Comment:

12 bp deletion in the single intron of Inx2.

(Mukai et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous females have tiny ovaries which contain no mature eggs. The ovarioles contain only early germ cells which resemble germline stem cells and cystoblasts. Fusomes are often not detected in the mutant germaria, and when they are present, they are unbranched. Follicle cells fail to form egg chambers in the mutant germarium.

      (Mukai et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Inx2FA42 has egg chamber phenotype, suppressible by shgUAS.sgGFP/Scer\GAL4hs.PU

      (Mukai et al., 2011)
      Other
      Statement
      Reference

      Inx2FA42, zpg[+]/zpgz-5352 has female germline cell phenotype

      (Mukai et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of shgScer\UAS.T:Avic\GFP-rs under the control of Scer\GAL4hs.PU partially rescues the formation of egg chambers in Inx2FA42 females.

      Expression of Egfr1.A887T.Scer\UAS under the control of Scer\GAL4hs.PU partially restores cyst formation in Inx2FA42 females (branched fusomes are observed in 77% of cases), but the formation of egg chambers is not rescued in these females.

      The addition of zpgz-5352/+ significantly reduces the number of germ cells in the germaria in Inx2FA42 females.

      (Mukai et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Inx2G0016

      (Mukai et al., 2011)
      Partially rescued by

      Inx2FA42 is partially rescued by Inx2UAS.cBa/Scer\GAL4hs.PU

      (Mukai et al., 2011)
      Comments

      Expression of Inx2Scer\UAS.cBa under the control of Scer\GAL4hs.PU partially rescues the sterility of Inx2FA42 homozygous females: 51.9% of ovaries are able to produce mature eggs in the rescued females.

      (Mukai et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      FA42
      (Mukai et al., 2011)
      Inx2FA42
      inx2FA42
      Name Synonyms
      Secondary FlyBase IDs
        References (1)