FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Inx2
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General Information
Symbol
Dmel\Inx2
Species
D. melanogaster
Name
Innexin 2
Annotation Symbol
CG4590
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027108
Gene Model Status
Current
Stock Availability
23 publicly available
Gene Summary
Innexin 2 (Inx2) encodes a gap junction protein that can form heteromeric gap junction channels via interaction with the products of ogre or Inx3. It can also interact with cell adhesion forming components encoded by shg and arm. It contributes to epithelial organization and polarity of the embryonic epidermis, regulation of morphogen-dependent organ size and stem cell behavior. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

prp33, kropf, l(1)G0035, l(1)G0043, l(1)G0118

Key Links
Genomic Location
Cytogenetic map
6E4-6E4
Sequence location
Recombination map
1-18
RefSeq locus
NC_004354 REGION:6998672..7004151
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables gap junction channel activity
inferred from direct assay
(Stebbings et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables gap junction channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000223951
(GO Reference Genome Project, 2011-)
inferred by curator from GO:0005921
(Bohrmann and Zimmermann, 2008)
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in cell communication
inferred from direct assay
(Bohrmann and Zimmermann, 2008)
involved_in foregut morphogenesis
inferred from mutant phenotype
(Bauer et al., 2002)
involved_in germarium-derived egg chamber formation
inferred from mutant phenotype
(Mukai et al., 2011)
involved_in germarium-derived female germ-line cyst formation
inferred from mutant phenotype
(Mukai et al., 2011)
involved_in intercellular transport
inferred from direct assay
(Stebbings et al., 2000)
involved_in male germ-line stem cell population maintenance
inferred from mutant phenotype
(Smendziuk et al., 2015)
involved_in morphogenesis of embryonic epithelium
inferred from mutant phenotype
(Bauer et al., 2004)
involved_in spermatogenesis
inferred from mutant phenotype
(Smendziuk et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in phototransduction
inferred from biological aspect of ancestor with PANTHER:PTN000934659
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(Bohrmann and Zimmermann, 2008)
located_in apicolateral plasma membrane
inferred from direct assay
(Bohrmann and Zimmermann, 2008)
located_in gap junction
inferred from direct assay
(Curtin et al., 1999)
inferred from direct assay
(Giuliani et al., 2013, Bohrmann and Zimmermann, 2008, Stebbings et al., 2000)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in gap junction
inferred from biological aspect of ancestor with PANTHER:PTN000223951
(GO Reference Genome Project, 2011-)
located_in membrane
non-traceable author statement
(Curtin et al., 1999)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000223951
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the pannexin family. (Q9V427)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Innexin 2 (Inx2) encodes a gap junction protein that can form heteromeric gap junction channels via interaction with the products of ogre or Inx3. It can also interact with cell adhesion forming components encoded by shg and arm. It contributes to epithelial organization and polarity of the embryonic epidermis, regulation of morphogen-dependent organ size and stem cell behavior. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
INNEXINS -
Gap junctions are intercellular channels that link the cytoplasm of neighboring cells facilitating cell-cell communication. In non-chordates they are composed of innexins. Innexins are four transmembrane proteins that assemble into hexamers around a central channel. The association of hemichannels on adjacent membranes forms the gap junction which allows the direct passage of ions and small molecules. Gap junctions may be formed from homo- or heteromultimers. (Adapted from FBrf0219962).
Protein Function (UniProtKB)
Structural components of the gap junctions. Involved in gap junctional communication between germline and somatic cells which is essential for normal oogenesis. In embryonic epidermis, required for epithelial morphogenesis. Required for keyhole formation during early stages of proventriculus development in response to wg signaling. In follicle cells, promotes the formation of egg chambers in part through regulation of shg and baz at the boundary between germ cells and follicle cells. In inner germarial sheath cells, required for survival of early germ cells and for cyst formation.
(UniProt, Q9V427)
Summary (Interactive Fly)

gap junction protein functioning in blood-brain barrier glia - mediate the influence of metabolic changes on stem cell behavior; response of glia to nutritional signals

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Inx2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V427)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Inx2-RA
FBtr0071005
NM_132147
2316
367
Inx2-RB
FBtr0071006
NM_167104
2758
367
Inx2-RC
FBtr0301860
NM_001169213
1832
367
Inx2-RD
FBtr0332314
NM_001272372
5266
367
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Inx2-PA
FBpp0070965
42.5
367
6.24
Q9V427
NP_572375
AAF46229
Inx2-PB
FBpp0070966
42.5
367
6.24
Q9V427
NP_727150
AAN09193
Inx2-PC
FBpp0291074
42.5
367
6.24
Q9V427
NP_001162684
ACZ95220
Inx2-PD
FBpp0304593
42.5
367
6.24
Q9V427
NP_001259301
AGB95146
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

367 aa isoforms: Inx2-PA, Inx2-PB, Inx2-PC, Inx2-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Monomer and heterooligomer with ogre or Inx3 (via cytoplasmic C-terminal region). Interacts (via cytoplasmic loop) with shg (via cytoplasmic region). Interacts with arm.

(UniProt, Q9V427)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Inx2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.70

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 5
embryonic cortex
(Curtin et al., 1999)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 8
cephalic furrow
(Curtin et al., 1999)
germ band
(Curtin et al., 1999)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
antennal primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
larval foregut atrium
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012, Lechner et al., 2007)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval tracheal dorsal trunk
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
embryonic stage 16 -- 17
embryonic/larval epidermis | segmentally repeated
(Curtin et al., 1999)
embryonic/larval proventriculus
(Curtin et al., 1999)
embryonic/larval foregut
(Curtin et al., 1999)
embryonic/larval hindgut
(Curtin et al., 1999)
embryonic stage 17
embryonic/larval proventriculus
(Lechner et al., 2007)
adult stage
lamina
(Curtin et al., 1999)
adult stage | female
follicle stem cell
(Mukai et al., 2011)
escort cell
(Mukai et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Inx2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 41 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Inx2
Transgenic constructs containing regulatory region of Inx2
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(1)Sxl-bt
(Mukai et al., 2011)
Gene duplicated in
Dp(1;3)DC489
(Popodi et al., 2010-)
Inferred from location ( 9 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW
lethal, with Scer\GAL4elav-C155
lethal | embryonic stage
lethal | embryonic stage | recessive
lethal | female
lethal | larval stage
lethal | larval stage | recessive
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4repo.PL
lethal - all die before end of pupal stage
lethal - all die during embryonic stage
lethal - all die during embryonic stage, with Scer\GAL4repo
lethal - all die during first instar larval stage
partially lethal, with Scer\GAL4arm.PS
partially lethal, with Scer\GAL4how-24B
partially lethal - majority die | recessive
viable
viable, with Scer\GAL4elav-C155
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female sterile (with Inx2FA42)
female sterile (with Inx2G0118)
female sterile | recessive
semi-sterile, with Scer\GAL4tj.PU
Other Phenotypes
Allele
abnormal cell shape
abnormal endomitotic cell cycle | oogenesis, with Scer\GAL4NP1624
abnormal feeding behavior | larval stage
abnormal neurophysiology, with Scer\GAL4Mz709
abnormal smell perception
abnormal visual behavior, with Scer\GAL4Mz709
decreased body size | embryonic stage
decreased cell number | adult stage, with Scer\GAL4tj.PU
decreased cell size | somatic clone
decreased occurrence of cell division | adult stage, with Scer\GAL4tj.PU
decreased occurrence of cell division | larval stage, with Scer\GAL4c311
decreased size | adult stage, with Scer\GAL4c311
decreased size | adult stage, with Scer\GAL4ey.PH
decreased size | adult stage, with Scer\GAL4eya.PB
decreased size | adult stage, with Scer\GAL4NP2631
decreased size | oogenesis, with Scer\GAL4NP1624
decreased size | oogenesis | somatic clone
increased cell death | embryonic stage, with Scer\GAL4VP16.mat.αTub67C
increased cell death | embryonic stage | rescuable maternal effect
increased cell number | adult stage, with Scer\GAL4tj.PU
increased size | oogenesis, with Scer\GAL4NP1624
long lived, with Scer\GAL4repo.PL
short lived | nutrition conditional, with Scer\GAL4repo.PL
some die during embryonic stage
some die during larval stage
some die during pupal stage
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4c311
visible | adult stage, with Scer\GAL4ey.200.Exel
visible | adult stage, with Scer\GAL4eya.PB
visible | adult stage, with Scer\GAL4NP2631
Phenotype manifest in
Allele
egg chamber
egg chamber, with Scer\GAL4NP1624
egg chamber | somatic clone
embryonic/first instar larval cuticle | rescuable maternal effect
embryonic/larval proventriculus
embryonic epidermis, with Scer\GAL4VP16.mat.αTub67C
embryonic epidermis | rescuable maternal effect
embryonic foregut
embryonic head
embryonic hindgut
embryonic Malpighian tubule
embryonic segment
eye, with Scer\GAL4c311
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4eya.PB
eye, with Scer\GAL4NP2631
eye disc, with Scer\GAL4c311
eye disc | somatic clone
female germline cell, with Scer\GAL4C587
female germline cyst, with Scer\GAL4NP1624
germarium, with Scer\GAL4C587
male germline stem cell, with Scer\GAL4tj.PU
ovary
ovary, with Scer\GAL4C587
ovary, with Scer\GAL4NP1624
ovary (with Inx2FA42)
ovary (with Inx2G0118)
P-body | oogenesis, with Scer\GAL4NP1624
photoreceptor neuron, with Scer\GAL4Mz709
presumptive embryonic/larval tracheal system
presumptive embryonic salivary gland
proventriculus primordium
somatic cell of testis, with Scer\GAL4tj.PU
synaptic vesicle, with Scer\GAL4Mz709
testis, with Scer\GAL4tj.PU
trichogen cell, with Scer\GAL4pnr-MD237
vibrissal bristle | absent | adult stage, with Scer\GAL4ey.200.Exel
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Panx3
1 of 14
Yes
Yes
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (25)
Cele\inx-7
10 of 14
Yes
Yes
Cele\che-7
9 of 14
No
No
Cele\inx-5
9 of 14
No
No
Cele\inx-6
9 of 14
No
No
Cele\inx-10
9 of 14
No
Yes
Cele\inx-11
9 of 14
No
Yes
Cele\inx-12
9 of 14
No
Yes
Cele\inx-16
9 of 14
No
Yes
Cele\inx-20
9 of 14
No
Yes
Cele\unc-9
9 of 14
No
No
Cele\eat-5
8 of 14
No
Yes
Cele\inx-1
8 of 14
No
No
Cele\inx-2
8 of 14
No
Yes
Cele\inx-3
8 of 14
No
No
Cele\inx-8
8 of 14
No
Yes
Cele\inx-9
8 of 14
No
Yes
Cele\inx-13
8 of 14
No
No
Cele\inx-15
8 of 14
No
Yes
Cele\inx-17
8 of 14
No
Yes
Cele\inx-18
8 of 14
No
No
Cele\inx-19
8 of 14
No
No
Cele\unc-7
8 of 14
No
No
Cele\inx-14
3 of 14
No
Yes
Cele\inx-22
3 of 14
No
No
Cele\inx-21
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP001488
11 of 12
Yes
Yes
Agam\AgaP_AGAP001476
6 of 12
No
No
Agam\AgaP_AGAP001477
6 of 12
No
No
Agam\AgaP_AGAP004510
6 of 12
No
No
Agam\AgaP_AGAP006241
5 of 12
No
No
Agam\SHAKB_ANOGA
5 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Inx2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
Inx3
9 of 13
Inx5
9 of 13
Inx6
9 of 13
Inx7
9 of 13
ogre
9 of 13
shakB
9 of 13
zpg
9 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Inx2
    suppressible
    coch
    (Vachias et al., 2025)
    Inx2
    enhanceable
    Inx3
    (Stebbings et al., 2000)
    Inx2
    suppressible
    shg
    (Mukai et al., 2011)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Inx3
    suppressible
    Inx2
    (Richard et al., 2017)
    Pten
    suppressible
    Inx2
    (Vachias et al., 2025)
    External Data
    Subunit Structure (UniProtKB)
    Monomer and heterooligomer with ogre or Inx3 (via cytoplasmic C-terminal region). Interacts (via cytoplasmic loop) with shg (via cytoplasmic region). Interacts with arm.
    (UniProt, Q9V427 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-18
    Cytogenetic map
    6E4-6E4
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    6E4-6E4
    Limits computationally determined from genome sequence between P{EP}inx7EP1641 and P{EP}CG9650EP1340&P{EP}CG9650EP1617
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    6F1-6F2
    (determined by in situ hybridisation) 6F1--4 (determined by in situ hybridisation) 6F5--6 (determined by in situ hybridisation) 6E1--2 (determined by in situ hybridisation) 6F1--8 (determined by in situ hybridisation)
    (Peter et al., 2002)
    6E4-6E5
    (Curtin, 1999.3.25, Stebbings, 1999.7.25)
    6E4-6E5
    (determined by in situ hybridisation)
    (Stebbings et al., 2000, Curtin et al., 1999)
    6F1-6F8
    (determined by in situ hybridisation)
    (Schäfer et al., 1999.12.14)
    6F1-6F2
    (determined by in situ hybridisation)
    (Schäfer et al., 1999.8.12)
    6E1-6E5
    (determined by in situ hybridisation) 6F1--4 (determined by in situ hybridisation) 6F (determined by in situ hybridisation) 6E4--5 (determined by in situ hybridisation) 6F1--2 (determined by in situ hybridisation)
    (Schäfer et al., 1999.6.15)
    6E1-6E2
    (determined by in situ hybridisation) 6E4--5 (determined by in situ hybridisation) 6F1--2 (determined by in situ hybridisation)
    (Schäfer et al., 1999.3.29)
    Experimentally Determined Recombination Data
    Location

    1-18

    (FlyBase, 2016)

    1-20.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (23)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (492)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Ammer et al., 2022, Huang et al., 2021, Smendziuk et al., 2015, Holcroft et al., 2013, Bohrmann and Zimmermann, 2008)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Inx2 is required in the soma for germline stem cell maintenance and germline differentiation in the testis. Together with zpg protein located on the germline side, it forms a heterotypic gap junction which links the soma and the germline.

          (Smendziuk et al., 2015)

          inx2 is required for the normal formation of the keyhole, a primordial structure of the proventriculus.

          (Bauer et al., 2002)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: inx2 l(1)G0036

          (Bauer et al., 2002)

          Source for merge of: inx2 l(1)G0036 l(1)G0317 l(1)G0035 l(1)G0157 l(1)G0059 l(1)G0118 l(1)G0043 l(1)G0364

          (Peter et al., 2002)
          Additional comments

          "l(1)G0011" may affect "inx2".

          (Peter et al., 2002)
          Nomenclature History
          Source for database identify of

          Source for identity of: Inx2 inx2

          (FlyBase, 2009-)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (29)
          Reported As
          Symbol Synonym
          CG4590
          (Jaspers et al., 2012, Tsubouchi et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Quinones-Coello, 2007, Bourbon et al., 2002)
          D-inx-2
          (Curtin et al., 2002)
          Dm-Inx2
          (Hasegawa and Turnbull, 2014)
          Dm-inx
          (Lehmann et al., 2001)
          Dm-inx2
          (Phelan and Starich, 2001, Stebbings et al., 2000)
          FBpp0291074
          (Abascal and Zardoya, 2013)
          INX-2
          (Wei et al., 2005)
          Inx-2
          (Merkle et al., 2020)
          Inx2
          (Ahmad et al., 2025, Bischoff et al., 2025, Boumard et al., 2025, Grzeschik et al., 2025, Luedke et al., 2024, Prelic et al., 2024, Barbaste et al., 2023, Petsakou and Perrimon, 2023, Petsakou et al., 2023, Stevens et al., 2023, Tu et al., 2023, Jia et al., 2022, Weiss et al., 2022, O'Connor et al., 2021, Sahu et al., 2021, Cho et al., 2020, Jefferies et al., 2020, Miao et al., 2020, Brodskiy et al., 2019, He et al., 2019, Meltzer et al., 2019, Raad and Robichon, 2019, Volkenhoff et al., 2018, Zhang et al., 2018, Richard et al., 2017, Transgenic RNAi Project members, 2017-, Pézier et al., 2016, Jambor et al., 2015, Richard and Hoch, 2015, Smendziuk et al., 2015, Chaturvedi et al., 2014, Hughes, 2014, Giuliani et al., 2013, Holcroft et al., 2013, Yamamoto et al., 2013-, Bohrmann and Zimmermann, 2008, Lechner et al., 2007, Lehmann et al., 2006, Kim et al., 2005, Brody et al., 2002)
          Ix2
          (Davies, 1999.9.16, Stebbings et al., 1999)
          inx-2
          (Chiusano et al., 2005, Tazuke et al., 2002)
          inx2
          (Choi et al., 2025, Ho et al., 2023, Ammer et al., 2022, Schotthöfer and Bohrmann, 2020, Shyu et al., 2019, Han et al., 2017, Hasegawa et al., 2017, Liu et al., 2016, Smendziuk et al., 2015, DeSalvo et al., 2014, Spéder and Brand, 2014, Ayukawa et al., 2012, Tsubouchi et al., 2012, Mukai et al., 2011, Wu et al., 2011, Popodi et al., 2010-, Quijano et al., 2008, Lechner et al., 2007, Quinones-Coello, 2007, Reiter et al., 2007, Lehmann et al., 2006)
          kropf
          (Giuliani et al., 2013, Lechner et al., 2007, Lehmann et al., 2006, Bauer et al., 2002)
          l(1)G0035
          (Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)
          l(1)G0036
          (Schäfer et al., 1999.6.15)
          l(1)G0043
          (Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)
          l(1)G0059
          (Schäfer et al., 1999.3.29)
          l(1)G0118
          (Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)
          l(1)G0157
          (Schäfer et al., 1999.8.12)
          l(1)G0317
          (Schäfer et al., 1999.6.15)
          l(1)G0364
          (Schäfer et al., 1999.12.14)
          prp33
          (Curtin, 1999.3.25, Curtin et al., 1999, Davies and Curtin, 1999.9.30)
          Name Synonyms
          Innexin
          (Wei et al., 2005)
          Innexin 2
          (Sahu et al., 2021, Spéder and Brand, 2014)
          Innexin-2
          (Abascal and Zardoya, 2013)
          Innexin2
          (Sahu et al., 2021, Holcroft et al., 2013)
          innexin 2
          (Jaspers et al., 2012, Tsubouchi et al., 2012, Cammarato et al., 2011, Bohrmann and Zimmermann, 2008, Sambandan et al., 2008, Sambandan et al., 2006, Ostrowski et al., 2005, Goulding et al., 2004, Bauer et al., 2003)
          innexin2
          (Mukai et al., 2011, Lechner et al., 2007, Lehmann et al., 2006, Lehmann et al., 2006)
          pas related protein 33
          (Curtin et al., 1999)
          Secondary FlyBase IDs
          • FBgn0026672
          • FBgn0026693
          • FBgn0026703
          • FBgn0026707
          • FBgn0027220
          • FBgn0027325
          • FBgn0028356
          • FBgn0029062
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 56 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          References (148)