- Tools
- Downloads
- Links
- Community
- About
- Help
FB2026_01
,
released March 12, 2026
inx1, l(1)ogre, innexin 1
gap junction protein functioning in blood-brain barrier glia - mediate the influence of metabolic changes on stem cell behavior; response of glia to nutritional signals
Please see the JBrowse view of Dmel\ogre for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.42
Gene model reviewed during 5.55
2.9 (northern blot)
362 (aa); 43 (kD)
Heterooligomer of Inx2 and ogre.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ogre using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
ogre protein is found in optic formation centers and giant neuroblasts in third instar larvae.
JBrowse - Visual display of RNA-Seq signals
View Dmel\ogre in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
ogre RNA and protein expression during development has been studied.
Genetic and developmental studies have indicated that the wild type function of ogre is crucial for and specific to postembryonic neurogenesis.
Developmental analysis has shown that effect of mutations at the locus are restricted to the developing and adult CNS. The time of ogre gene action is during the early and late larval period.
Original allele (ogre1) recovered on the basis of simple lethality (Niklas and Cline, 1983); viable mutant (ogre2) isolated with respect to inability of adults to orient to vertical line of black-white contrast (Lipshitz and Kankel, 1985); optic lobes generally disorganized, as seen in adults expressing the viable allele, or in late pupae/pharate adults expressing a lethal allele; such lethals (all except ogre2) cause the behavioral and anatomical abnormalities just noted when heterozygous with viable allele; viability associated with one of these heteroallelic types, i.e., ogre1/ogre2 is poor, especially when reared at 18oC (vs 29oC); temperature shift experiments using this combination implies gene action in late larval stage; hemizygosity for lethal alleles causes development to cease in late larval-pupal stages, when parts of CNS appear abnormal (e.g., holes in sections of brain and thoracic ganglia, with severe defects appearing in the optic lobe formation centers); holes in CNS are also seen in 'escapers', e.g., rare adults hemizygous for alleles other than ogre2, or heterozygous for ogre1 and ogre2; mosaic analysis suggests that CNS defects are due to action of this gene in those developing tissues (Lipshitz and Kankel, 1985).
Source for merge of: ogre CG3039
