FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SKDN.UAS.Tag:MYC
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General Information
Symbol
Dmel\SKDN.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0266129
Feature type
allele
Associated gene
Dmel\SK
Associated Insertion(s)
Carried in Construct
P{UAS-SK.DN.myc}
Key Links
Transgenic product class
missense_variant
(Abou Tayoun et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Abou Tayoun et al., 2011)
Mutagen
in vitro construct
(Abou Tayoun et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-SK.DN.myc}
Cytology
Description

Amino acid replacement: G?A.

(Abou Tayoun et al., 2011)

UAS regulatory sequences drive expression of SK short isoform coding sequences (corresponding to EST GH16664) with the K[+} pore residues (GYG) mutated to (AAA), tagged at the C-terminal with Tag:MYC.

(Abou Tayoun et al., 2011)

Amino acid replacement: Y?A.

(Abou Tayoun et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
SK
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SKDN.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.long in a wild-type background completely suppresses the SK current induced from photoreceptors using either the ion exchange protocol or 1-Ethyl-2-benzimidazolinone in dissociated ommatidia.

      Intracellular recordings from photoreceptors expressing SKDN.Scer\UAS.T:Hsap\MYC (under the control of Scer\GAL4GMR.long) show accelerated response kinetics. However, no light-dependent oscillations are detected in such photoreceptors, although there conductance deficits match those of SK1 photoreceptors.

      (Abou Tayoun et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SKDN.Scer\UAS.T:Hsap\MYC
      SKDN.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)