FB2026_02 , released June 18, 2026
Allele: Dmel\Xport-A1
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General Information
Symbol
Dmel\Xport-A1
Species
D. melanogaster
Name
FlyBase ID
FBal0266159
Feature type
allele
Associated gene
Dmel\Xport-A
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Rosenbaum et al., 2011)
Mutagen
ethyl methanesulfonate
(Rosenbaum et al., 2011)
Progenitor genotype
Cytology
Description

The Xport-B protein is still expressed in Xport-A1 mutants (expression of the Xport-A protein is eliminated).

(Chen et al., 2015)

Nucleotide substitution: C145T.

(Rosenbaum et al., 2011)

Amino acid replacement: Q49term.

(Rosenbaum et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:19,915,150..19,915,150 [-]
Nucleotide change:

C19915150T

Reported nucleotide change:

C?T

Amino acid change:

Q49term | Xport-A-PA

Reported amino acid change:

Q49term

(Rosenbaum et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant adults show only a transient electroretinogram response to light, in contrast to the sustained response seen in wild-type flies.

      Mutant adults show severe retinal degeneration at 14 days of age (raised under light:dark conditions).

      (Chen et al., 2015)

      Mutants show an abnormal, transient response during prolonged light stimulation compared to wild type.

      The response amplitude of dissociated Xport1 ommatidia to brief light flashes are ~20 fold reduced.

      Mutants display early onset retinal degeneration. Rhabdomeres are diminished in size in 1-day-old mutants grown on a 12;12 hour light:dark cycle, and photoreceptor cells display extensive ER membrane accumulations and dilated Golgi. At 2 weeks, the mutant photoreceptors are severely degenerated and all rhabdomeres are vastly reduced or missing. Dark-reared flies still show ER membrane accumulation and dilated Golgi but exhibit nearly normal rhabdomere morphology.

      (Rosenbaum et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Xport-A1 has abnormal neurophysiology | adult stage phenotype, enhanceable by trplMB10553

      (Chen et al., 2015)

      Xport-A1 has abnormal neurophysiology phenotype, enhanceable by trpl302

      (Rosenbaum et al., 2011)
      NOT suppressed by
      Statement
      Reference

      Xport-A1 has abnormal neurophysiology | adult stage phenotype, non-suppressible by Xport-BninaE.PC

      (Chen et al., 2015)
      NOT Enhancer of
      Statement
      Reference

      Xport-A1 is a non-enhancer of abnormal neurophysiology | adult stage phenotype of trpMB03672

      (Chen et al., 2015)
      NOT Suppressor of
      Statement
      Reference

      Xport-A1 is a non-suppressor of abnormal neurophysiology | adult stage phenotype of trpMB03672

      (Chen et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Xport-BninaE.PC does not rescue the electroretinogram defects of Xport-A1 adults.

      The electroretinogram defects seen in trpMB03672 flies are not altered if the flies are also mutant for Xport-A1.

      trplMB10553 enhances the electroretinogram defects seen in Xport-A1 flies.

      (Chen et al., 2015)

      Dissociated Xport1, trpl302 double mutant ommatidia show a residual response to brief light flashes; sensitivity is reduced ~500-fold with respect to wild type and 25-fold with respect to Xport1.

      (Rosenbaum et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Xport-A1 is rescued by Xport-AninaE.PC

      (Chen et al., 2015)

      Xport-A1 is rescued by Xport-AninaE.Tag:SBP

      (Chen et al., 2015)

      Xport-A1 is rescued by Xport-AninaE.PR

      (Rosenbaum et al., 2011)
      Comments

      Expression of Xport-AninaE.PC or Xport-AninaE.T:Zzzz\SBP rescues the electroretinogram defects of Xport-A1 adults.

      (Chen et al., 2015)

      XportninaE.PR restores the response amplitude of dissociated Xport1 ommatidia to brief light flashes, and rescues Xport1 retinal pathology.

      (Rosenbaum et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Xport-A1
      Xport1
      XportA1
      (Gaspar et al., 2022)
      xport1
      (Rosenbaum et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)