FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\paraUAS.1-1
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General Information
Symbol
Dmel\paraUAS.1-1
Species
D. melanogaster
Name
FlyBase ID
FBal0266200
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
P{UAS-para.1-1}
Key Links
Transgenic product class
wild_type
(Parker et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Parker et al., 2011)
Mutagen
in vitro construct
(Parker et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-para.1-1}
Cytology
Description

UAS regulatory sequences drive expression of the wild-type para 1-1 isoform.

(Parker et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
para
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  developmental and epileptic encephalopathy 64
      modeled by RhoBTBUAS.cSa
      (Langhammer et al., 2025)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/paraUAS.1-1 rescues parabss1

      (Parker et al., 2011)
      Comments

      Expression of paraScer\UAS.1-1 under the control of Scer\GAL4elav-C155 suppresses the bang sensitive phenotype seen in parabss1/+ females (the phenotype is completely suppressed when two copies of paraScer\UAS.1-1 are used).

      Expression of paraScer\UAS.1-1 under the control of Scer\GAL4elav-C155 is also effective at rescuing the bang sensitive phenotype seen in parabss1/Y males (the penetrance of the phenotype is reduced and the seizure threshold is significantly increased).

      (Parker et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      paraScer\UAS.1-1
      paraUAS.1-1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)