FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\paraL1699F.UAS.1-1
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General Information
Symbol
Dmel\paraL1699F.UAS.1-1
Species
D. melanogaster
Name
FlyBase ID
FBal0266201
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
P{UAS-para.1-1.L1699F}
Key Links
Transgenic product class
missense_variant
(Parker et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Parker et al., 2011)
Mutagen
in vitro construct
(Parker et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-para.1-1.L1699F}
Cytology
Description

UAS regulatory sequences drive expression of the a mutated for of the para 1-1 isoform which contains the amino acid replacement L1699F (the same lesion as in the parabss1 mutant allele).

(Parker et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
para
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only 1.% of flies expressing paraL1699F.Scer\UAS.1-1 under the control of Scer\GAL4elav-C155 show bang-sensitive paralysis. The average recovery period for those flies that do paralyse is 33 seconds (which resembles the recovery time of parabss1/+ flies).

      Expression of two copies of paraL1699F.Scer\UAS.1-1 under the control of Scer\GAL4elav-C155 exacerbates the bang-sensitive phenotype of parabss1/+ females: the mean recovery time increases from 38 to 52 seconds and the seizure threshold decreases from 19.1 to 12.1V.

      (Parker et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      paraL1699F.Scer\UAS.1-1
      paraL1699F.UAS.1-1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)