FlyBase Allele Report: Dmel\SA1[GL00534]

General Information

Symbol

Dmel\SA1^GL00534

Species

D. melanogaster

Name

FlyBase ID

FBal0266234

Feature type

allele

Associated gene

Dmel\SA1

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00534}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00534}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00534

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

oocyte

(Gyuricza et al., 2016)

synaptonemal complex | adult stage | female

(Gyuricza et al., 2016)

Detailed Description

Statement

Reference

Expression of SA^GL00534 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} results in incomplete synaptonemal complex assembly in oocytes and the average number of c(3)G-positive patches in oocytes significantly decreases between regions 2a and 3 compared to control germaria. The number of Cenp-C- or cid-labelled foci per cell in meiosis I oocytes is however not changed compared to wild-type, suggesting that sister-centromere adhesion is unaffected.

(Gyuricza et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

SA1^GL00534 has oocyte phenotype, non-suppressible by c(2)M^Z0810/c(2)M^EP2115

(Gyuricza et al., 2016)

SA1^GL00534 has synaptonemal complex | female | adult stage phenotype, non-suppressible by c(2)M^Z0810/c(2)M^EP2115

(Gyuricza et al., 2016)

Other

Statement

Reference

SA1^GL00534, Scer\GAL4^{VP16.nanos.UTR}, ord⁵/ord¹⁰ has ovary phenotype

(Gyuricza et al., 2016)

SA1^GL00534, Scer\GAL4^{VP16.nanos.UTR}, ord⁵/ord¹⁰ has female germline cell phenotype

(Gyuricza et al., 2016)

SA1^GL00534, Scer\GAL4^{VP16.nanos.UTR}, sunn^147-75/sunn^167-109 has ovary phenotype

(Gyuricza et al., 2016)

SA1^GL00534, Scer\GAL4^{VP16.nanos.UTR}, sunn^147-75/sunn^167-109 has female germline cell phenotype

(Gyuricza et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Combination with c(2)M^EP2115/c(2)M^Z0810 in transheterozygous state cannot suppress the decrease in average number of c(3)G-positive patches in oocytes between regions 2a and 3 of the germarium observed in flies expressing SA^GL00534 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

Expression of SA^GL00534 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in either the ord⁵/ord¹⁰ or the sunn^167-109/sunn^147-75 mutant background results in rudimentary ovaries lacking germ cells.

(Gyuricza et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36794

y¹ sc^* v¹ sev²¹; P{TRiP.GL00534}attP40/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

SA1^GL00534

SA^GL00534

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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