FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\kisGL00557
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General Information
Symbol
Dmel\kisGL00557
Species
D. melanogaster
Name
FlyBase ID
FBal0266257
Feature type
allele
Associated gene
Dmel\kis
Associated Insertion(s)
Carried in Construct
P{TRiP.GL00557}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.GL00557}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-GL00557
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Somatic clones expressing kisGL00557 under the control of Scer\GAL4Tub.PU contain a greater overall number of cells and significantly more intestinal stem cells in adult flies compared to controls.

      Expressing kisGL00557 under the control of either Scer\GAL4esg.PU alone or together with Scer\GAL80Su(H).GBE (both genotypes in combination with a Gal80[ts] transgene to restrict expression to the adult stage) induces stem cell overproliferation, resulting in a greater overall number of esg-positive cells and significantly more intestinal stem cells in adult flies compared to controls. No change in proliferation or cell number is observed when expression is under the control of Scer\GAL4NP0001, Scer\GAL4Su(H).GBE or Scer\GAL4pros-V1 (each in combination with a Gal80[ts] transgene to restrict expression to the adult stage).

      (Gervais et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      kisGL00557
      Name Synonyms
      Secondary FlyBase IDs
        References (4)