FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cdc7GL00585
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General Information
Symbol
Dmel\Cdc7GL00585
Species
D. melanogaster
Name
FlyBase ID
FBal0266285
Feature type
allele
Associated gene
Dmel\Cdc7
Associated Insertion(s)
Carried in Construct
P{TRiP.GL00585}
Also Known As
GL00585
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.GL00585}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-GL00585
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Cdc7GL00585 under the control of Scer\GAL4VP16.mat.αTub67C in the mother results in multiple unevenly-distributed, highly fragmented DNA masses in the embryo interior, along with scattered abnormal mitotic structures; nuclei fail to form a blastoderm, but centrosomes often continue to duplicate in the absence of any associated DNA.

      (Seller and O'Farrell, 2018)

      Females heterozygous for Cdc7GL00585 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to Cdc7GL00585 males results in: 20% hatching; egg/embryonic phenotype: "empty, all white"; maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rif1KO homozygosity, but not heterozygosity in mothers expressing Cdc7GL00585 under the control of Scer\GAL4VP16.mat.αTub67C restores cell cycle progression, with most embryos reaching the blastoderm stage; nuclear abnormalities still occur, but some embryos (a minority) survive and hatch.

      (Seller and O'Farrell, 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cdc7GL00585
      l(1)G0148GL00585
      Name Synonyms
      Secondary FlyBase IDs
        References (3)