FlyBase Allele Report: Dmel\pum[HMS01564]

General Information

Symbol

Dmel\pum^HMS01564

Species

D. melanogaster

Name

FlyBase ID

FBal0266471

Feature type

allele

Associated gene

Dmel\pum

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01564}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01564}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01564

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa

(Collins et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

pum^HMS01564, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Scer\GAL4^GMR.PU

(Collins et al., 2023)

Other

Statement

Reference

Rbf^HMS03004, Scer\GAL4^nub.PU, pum^HMS01564 has visible | adult stage phenotype

(Miles et al., 2014)

E2f2^JF02828, Scer\GAL4^nub.PU, pum^HMS01564 has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip120^HMS00461, pum^HMS01564 has visible | adult stage phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, pum^HMS01564 has visible | adult stage phenotype

(Miles et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

pum^HMS01564, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Scer\GAL4^GMR.PU

(Collins et al., 2023)

Suppressor of

Statement

Reference

pum^HMS01564, Scer\GAL4^bam.PU is a suppressor | partially of egg chamber phenotype of Rbfox1^RNAi.UASp, Scer\GAL4^bam.PU

(Carreira-Rosario et al., 2016)

pum^HMS01564, Scer\GAL4^bam.PU is a suppressor | partially of nurse cell phenotype of Rbfox1^RNAi.UASp, Scer\GAL4^bam.PU

(Carreira-Rosario et al., 2016)

pum^HMS01564, Scer\GAL4^bam.PU is a suppressor | partially of female germline cell | increased number phenotype of Rbfox1^RNAi.UASp, Scer\GAL4^bam.PU

(Carreira-Rosario et al., 2016)

Other

Statement

Reference

Rbf^HMS03004, Scer\GAL4^nub.PU, pum^HMS01564 has wing blade phenotype

(Miles et al., 2014)

E2f2^JF02828, Scer\GAL4^nub.PU, pum^HMS01564 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip120^HMS00461, pum^HMS01564 has wing blade phenotype

(Miles et al., 2014)

Scer\GAL4^nub.PU, mip130^HMS00462, pum^HMS01564 has wing blade phenotype

(Miles et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of pum^HMS01564 partially suppresses the germ cell tumor phenotype in Scer\GAL4^bam.PU>Rbfox1^{dsRNA.shRNA.Scer\UAS.P\T} ovaries, resulting in an increase in the percentage of egg chambers containing nurse cells with polyploid nuclei.

(Carreira-Rosario et al., 2016)

Co-expression of any of the following: Rbf^HMS03004, E2f2^JF02828, mip130^HMS00462 or mip120^HMS00461 with pum^HMS01564 under the control of Scer\GAL4^nub.PU (using UAS-Dicer2 to enhance RNAi efficiency) results in severely blistered and deformed adult wings.

(Miles et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

36676