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General Information
Symbol
Dmel\Rbfox1dsRNA.shRNA.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0319039
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp regulatory sequences drive expression of a shRNA oligo targeting the unique exon present in the Rbfox1 RF/RN isoforms.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Rbfox1dsRNA.shRNA.Scer\UAS.P\T driven by Scer\GAL4nos.PU leads to a germ cell tumor phenotype (accumulation of germline cysts that fail to differentiate beyond early stages). Scer\GAL4bam.PU>Rbfox1dsRNA.shRNA.Scer\UAS.P\T egg chambers contain fewer polyploid nurse cells (around 25% of egg chambers) and have germ cell tumors (around 75%) (compared to 100%/0% in controls).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of pumHMS01564 partially suppresses the germ cell tumor phenotype in Scer\GAL4bam.PU>Rbfox1dsRNA.shRNA.Scer\UAS.P\T ovaries, resulting in an increase in the percentage of egg chambers containing nurse cells with polyploid nuclei.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Rbfox1dsRNA.shRNA.Scer\UAS.P\T
Rbfox1dsRNA.shRNA.UASp
Name Synonyms
Secondary FlyBase IDs
    References (1)