FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sema2aUAS.GFP,Tag:M(mCd8a)
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General Information
Symbol
Dmel\Sema2aUAS.GFP,Tag:M(mCd8a)
Species
D. melanogaster
Name
FlyBase ID
FBal0266708
Feature type
allele
Associated gene
Dmel\Sema2a
Associated Insertion(s)
Carried in Construct
P{UAS-Sema2a-TM-GFP}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Wu et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Sema2a-TM-GFP}
Cytology
Description

UAS regulatory sequences drive expression Sema2a which is tagged at the C-terminus with the transmembrane region of Mmus\Cd8a and with GFP.

(Wu et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sema2a
Tagged with
GFP
Tag:M(mCd8a)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Charcot-Marie-Tooth disease type 2D
      modeled by GlyRSP234KY-2.UAS
      (Grice et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sema2aUAS.GFP,Tag:M(mCd8a) under the control of Scer\GAL4GMR83H12 leads to subtle changes in P-Fr neurons process targeting when compared to control adults.

      (Xie et al., 2019)

      Embryos expressing Sema2aScer\UAS.T:Avic\GFP,T:Mmus\Cd8a under the control of Scer\GAL4twi.PG display significantly increased frequency of irregularities in the structure of embryonic salivary gland (SG) lumen compared to wild-type controls. Expression controlled by the Scer\GAL4fkh.PH driver leads to significant widening of the SG.

      (Hanlon and Andrew, 2016)

      24.9% of hemisegments show defects in the ISNb pathway (ISNb motor axons reach muscle 12 with no RP5 innervations) in embryos expressing one copy of Sema-2aScer\UAS.T:Avic\GFP,T:Mmus\Cd8a under the control of Scer\GAL4tey-5053A. The penetrance of the phenotype increases to 52.6% of hemisegments when two copies of Sema-2aScer\UAS.T:Avic\GFP,T:Mmus\Cd8a are used.

      (Wu et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sema-2aScer\UAS.T:Avic\GFP,T:Mmus\Cd8a
      Sema2aScer\UAS.T:Avic\GFP,T:Mmus\Cd8a
      Sema2aUAS.GFP,Tag:M(mCd8a)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)