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Wu, Z., Sweeney, L.B., Ayoob, J.C., Chak, K., Andreone, B.J., Ohyama, T., Kerr, R., Luo, L., Zlatic, M., Kolodkin, A.L. (2011). A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS.  Neuron 70(2): 281--298.
FlyBase ID
FBrf0213571
Publication Type
Research paper
Abstract

Longitudinal axon fascicles within the Drosophila embryonic CNS provide connections between body segments and are required for coordinated neural signaling along the anterior-posterior axis. We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (PlexB), but serve distinct guidance functions. Localized Sema-2b attraction promotes the initial assembly of a subset of CNS longitudinal projections and subsequent targeting of chordotonal sensory afferent axons to these same longitudinal connectives, whereas broader Sema-2a repulsion serves to prevent aberrant innervation. In the absence of Sema-2b or PlexB, chordotonal afferent connectivity within the CNS is severely disrupted, resulting in specific larval behavioral deficits. These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly.

PubMed ID
PubMed Central ID
PMC3095019 (PMC) (EuropePMC)
Related Publication(s)
Supplementary material
Personal communication to FlyBase

PBac{IbaS} endpoints.
Wu, 2016.8.29, PBac{IbaS} endpoints. [FBrf0233384]

Note

The coordinate regulation of sensory afferent CNS targeting and CNS longitudinal tract organization in Drosophila during neural development.
Wu et al., 2012, J. Peripher. Nerv. Syst. 17 Suppl 3: 34--37 [FBrf0220411]

Cracking the combinatorial semaphorin code.
Berke and Keshishian, 2011, Neuron 70(2): 175--177 [FBrf0213563]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference