FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sema2bUAS.GFP,Tag:M(mCd8a)
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General Information
Symbol
Dmel\Sema2bUAS.GFP,Tag:M(mCd8a)
Species
D. melanogaster
Name
FlyBase ID
FBal0266711
Feature type
allele
Associated gene
Dmel\Sema2b
Associated Insertion(s)
Carried in Construct
P{UAS-Sema2b-TM-GFP}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Wu et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Sema2b-TM-GFP}
Cytology
Description

UAS regulatory sequences drive expression Sema2b which is tagged at the C-terminus with the transmembrane region of Mmus\Cd8a and with GFP.

(Wu et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sema2b
Tagged with
GFP
Tag:M(mCd8a)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sema2bUAS.GFP,Tag:M(mCd8a) under the control of Scer\GAL4GMR83H12 leads to attraction of P-Fr processes to the ventral fan-shaped body and dorsal noduli in the adult brain when compared to controls.

      (Xie et al., 2019)

      5.4% of hemisegments show defects in the SNa pathway (the SNa lateral pathway ectopically contacts muscle 12) in embryos expressing one copy of Sema-2bScer\UAS.T:Avic\GFP,T:Mmus\Cd8a under the control of Scer\GAL4tey-5053A. The penetrance of the phenotype increases to 28.2% of hemisegments when two copies of Sema-2bScer\UAS.T:Avic\GFP,T:Mmus\Cd8a are used.

      (Wu et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Sema2bUAS.GFP,Tag:M(mCd8a)/Scer\GAL4A58 rescues Sema2bf02042/Df(2R)Sema2b-C4

      (Meltzer et al., 2016)
      Comments

      The increased dendritic non-contacting crossing in the class IV da neurons seen in Sema-2bf02042/Df(2R)Sema-2b-C4 mutant larvae can be rescued by ectopic expression of Sema-2bScer\UAS.cUa or Sema-2bScer\UAS.T:Avic\GFP,T:Mmus\Cd8a under the Scer\GAL4A58 driver, whereas expression of Sema-2bScer\UAS.cUa under Scer\GAL4ppk.PU does not rescue the phenotype.

      (Meltzer et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sema-2bScer\UAS.T:Avic\GFP,T:Mmus\Cd8a
      Sema2bScer\UAS.T:Avic\GFP,T:Mmus\Cd8a
      Sema2bUAS.GFP,Tag:M(mCd8a)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)