FlyBase Allele Report: Dmel\frac[Δ2]

General Information

Symbol

Dmel\frac^Δ2

Species

D. melanogaster

Name

FlyBase ID

FBal0266871

Feature type

allele

Associated gene

Dmel\frac

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

transposable element activity

Nature of the Allele

Allele class

Mutagen

transposable element activity

(Miller et al., 2011)

Progenitor genotype

Cytology

Description

Imprecise excision of Mi{ET1}frac^MB05690 results in a 2.1kb deletion, removing the first 3 exons and 2 introns of the frac gene.

(Miller et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Miller et al., 2011)

abnormal neuroanatomy | embryonic stage (with Df(3L)pbl-X1)

(Miller et al., 2011)

fertile

(Miller et al., 2011)

viable

(Miller et al., 2011)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage

(Miller et al., 2011)

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage (with Df(3L)pbl-X1)

(Miller et al., 2011)

larval segmental nerve branch SNa of A1-7 | embryonic stage

(Miller et al., 2011)

larval segmental nerve branch SNa of A1-7 | embryonic stage (with Df(3L)pbl-X1)

(Miller et al., 2011)

Detailed Description

Statement

Reference

frac^Δ2 mutants are viable and display no overt behavioural defects.

frac^Δ2 mutants do not display defects in muscle size, number, or epidermal attachment.

frac^Δ2 mutant embryos exhibit prominent axon guidance defects. Approximately 57% of frac^Δ2 mutant hemisegments exhibit aberrant ISNb branches. The penetrance of ISNb guidance defects is not affected by maternal frac levels.

Approximately 49% of hemisegments in frac^Δ2 contain axons that separate inappropriately and project ectopically. The majority of defects are hypo-fasciculation errors in which axons inappropriately branch away from SNa axons.

frac^Δ2/Df(3L)pbl-X1 mutants exhibit the same guidance defects as frac^Δ2 homozygotes.

(Miller et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

frac^Δ2

(Miller et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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