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General Information
Symbol
Dmel\Sema2bunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0266954
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
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    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
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    Disease
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    Disease
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    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    DL1 and VM2 projection neuron dendrites target normally to the dorsolateral DL1 glomerulus in homozygous flies.

    External Data
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    Phenotypic Class
    Phenotype Manifest In
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    Genetic Interactions
    Statement
    Reference

    Overall antennal lobe morphology is disrupted in Sema-2a03474 Sema-2bunspecified double homozygous flies. Dendrite targeting defects are seen for a number of projection neurons. The dendrites of the DL1 projection neurons are either split between the DL1 glomerulus (wild-type target) and an ectopic ventromedial position or entirely shifted ventromedially. DL3 projection neuron dendrites mistarget ventrally or ventromedially. VA1d and DA1 projection neuron dendrites mistarget ventromedially and ventrolaterally. VM2 projection neuron dendrites show significant dorsolateral mistargeting.

    Sema-2a03474/+ Sema-2bunspecified/Sema-2bunspecified flies show a small but significant ventromedial shift of Mmus\Cd8aMz19-positive projection neuron dendrite targeting. There is an additional significant ventromedial shift for these dendrites if the flies are also expressing Sema-2aGD5476 under the control of Scer\GAL4peb-GAL4.

    In Sema-2a03474 Sema-2bunspecified double mutant projection neuron anterodorsal neuroblast clones generated between 0-24 hours after larval hatching (ALH), VM2 projection neuron dendrites mistarget dorsolaterally. In contrast, if the double mutant clones are generated between 48-72 hours ALH, VM2 dendrites target normally to the ventromedial VM2 glomerulus.

    Xenogenetic Interactions
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    Complementation and Rescue Data
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    Mutant
    Wild-type
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    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Sema-2bunspecified
    Sema2bunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (1)