FlyBase Allele Report: Dmel\Atg1[K.GMR]

General Information

Symbol

Dmel\Atg1^K.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0267077

Feature type

allele

Associated gene

Dmel\Atg1

Associated Insertion(s)

Carried in Construct

P{GMR-Atg1.K}

Key Links

Transgenic product class

inframe_deletion

(Chen et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Chen et al., 2008)

Mutagen

in vitro construct

(Chen et al., 2008)

Progenitor genotype

Carried in construct

P{GMR-Atg1.K}

Cytology

Description

GMR regulatory sequences drive expression of the kinase domain (amino acids 1-378) of Atg1.

(Chen et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Atg1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size

(Chen et al., 2008)

increased cell death

(Chen et al., 2008)

visible

(Chen et al., 2008)

Phenotype Manifest In

eye

(Chen et al., 2008)

eye disc | third instar larval stage

(Chen et al., 2008)

Detailed Description

Statement

Reference

Atg1^K.GMR overexpression induces excess apoptosis in the developing eye imaginal discs.

Expression of Atg1^K.GMR results in a strong rough eye phenotype associated with substantial disruption of the external eye structure, and significant reduction in overall eye size.

(Chen et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Atg1^K.GMR has abnormal size phenotype, suppressible by Df(2L)pr-A16/+

(Chen et al., 2008)

Atg1^K.GMR has visible phenotype, suppressible by Df(2L)pr-A16/+

(Chen et al., 2008)

Atg1^K.GMR has increased cell death phenotype, suppressible by BacA\p35^GMR.PH

(Chen et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Atg1^K.GMR has eye phenotype, suppressible by Df(2L)pr-A16/+

(Chen et al., 2008)

Atg1^K.GMR has eye disc | third instar larval stage phenotype, suppressible by BacA\p35^GMR.PH

(Chen et al., 2008)

NOT suppressed by

Statement

Reference

Atg1^K.GMR has eye phenotype, non-suppressible by Fak^CG1/Fak56D[+]

(Chen et al., 2008)

Atg1^K.GMR has eye phenotype, non-suppressible by mys^G0091b/mys[+]

(Chen et al., 2008)

Atg1^K.GMR has eye phenotype, non-suppressible by mew[+]/mew^M6

(Chen et al., 2008)

Atg1^K.GMR has eye phenotype, non-suppressible by if^k27e/if[+]

(Chen et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Df(2L)pr-A16 can strongly suppress the Atg1^K.GMR-induced rough-eye phenotype.

(Chen et al., 2008)

Xenogenetic Interactions

Statement

Reference

The Atg1^K.GMR-induced excess apoptosis in eye discs can be suppressed by co-expressing BacA\p35^GMR.PH.

(Chen et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Atg1^K.GMR

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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