FB2026_02 , released June 18, 2026
Allele: Dmel\α-Est71
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General Information
Symbol
Dmel\α-Est71
Species
D. melanogaster
Name
FlyBase ID
FBal0267114
Feature type
allele
Associated gene
Dmel\α-Est7
Associated Insertion(s)
TI{TI}α-Est71
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Birner-Gruenberger et al., 2012)
Mutagen
ends-out gene targeting
(Birner-Gruenberger et al., 2012)
I-SceI
(Birner-Gruenberger et al., 2012)
FLPase
(Birner-Gruenberger et al., 2012)
Progenitor genotype
Associated Insertion(s)
TI{TI}α-Est71
Cytology
Description

All of α-Est7 except the first exon ( 3R:3 ,345,260..3,347,419 has been deleted) has been replaced by a mini-w marker.

(Birner-Gruenberger et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:7,519,538..7,521,697 [-]
Comment:

Ends-out homologous recombination results in a deletion of exons 2-6 of alpha-Est7, which are replaced with a a mini-w marker.

(Birner-Gruenberger et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      α-Est71 flies are weakly sensitive to the insecticide parent molecule 'diazinon'.

      The lipid stores of mutant flies are significantly reduced by 24%.

      There is no effect on female fecundity in α-Est71 flies.

      α-Est71 flies suffer from a median lifespan reduction between 6-14%.

      α-Est71 flies show no gross developmental defects and show no difference in fluctuating asymmetry (as measured by counting large and small sternopleural bristles) compared to controls.

      (Birner-Gruenberger et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      α-Est71
      (Birner-Gruenberger et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)