FB2026_02 , released June 18, 2026
Allele: Dmel\MAPk-Ak2Δ41
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General Information
Symbol
Dmel\MAPk-Ak2Δ41
Species
D. melanogaster
Name
FlyBase ID
FBal0267166
Feature type
allele
Associated gene
Dmel\MAPk-Ak2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Seisenbacher et al., 2011)
Mutagen
P-element activity
(Seisenbacher et al., 2011)
Progenitor genotype
P{EP}MAPk-Ak2GE3296
(Seisenbacher et al., 2011)
Cytology
Description

Excision of the P{EP} element in P{EP}MAPk-Ak2GE3296 results in deletion of the region upstream of the insertion site, which includes the first exon of MAPk-Ak2.

(Seisenbacher et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Approximately 25% of MAPk-Ak2Δ41 mutant larvae exhibit a melanotic phenotype in response to strong salt stress (0.2M NaCl). A "black dot" is seen in the posterior hindgut and the affected hindgut epithelium appears pathologically altered. Very few mutants exhibit this phenotype when raised on food containing 0.1M NaCl, or on normal food.

      (Seisenbacher et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MAPk-Ak2Δ41
      Δ41
      (Seisenbacher et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)