FlyBase Allele Report: Dmel\Col4a1[hs.9.7]

General Information

Symbol

Dmel\Col4a1^hs.9.7

Species

D. melanogaster

Name

FlyBase ID

FBal0267186

Feature type

allele

Associated gene

Dmel\Col4a1

Associated Insertion(s)

Carried in Construct

P{hs-Col4a1.9.7}

Key Links

Transgenic product class

genomic_DNA

(Kelemen-Valkony et al., 2012)

wild_type

(Kelemen-Valkony et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Kelemen-Valkony et al., 2012)

wild_type

(Kelemen-Valkony et al., 2012)

Mutagen

in vitro construct

(Kelemen-Valkony et al., 2012)

Progenitor genotype

Carried in construct

P{hs-Col4a1.9.7}

Cytology

Description

A hsp70 promoter drives expression of a 9.7kb genomic fragment containing the entire Cg25C gene.

(Kelemen-Valkony et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Col4a1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Kelemen-Valkony et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Col4a1^hs.9.7 is a non-suppressor of lethal phenotype of vkg^b-14/vkg^b-35

(Kelemen-Valkony et al., 2012)

Col4a1^hs.9.7 is a non-suppressor of lethal phenotype of vkg^sz-14/vkg^b-35

(Kelemen-Valkony et al., 2012)

Col4a1^hs.9.7 is a non-suppressor of lethal phenotype of vkg^sz-14/vkg^b-14

(Kelemen-Valkony et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Cg25C^hs.9.7 is unable to suppress the recessive lethality seen in vkg^sz-14/vkg^b-35 mutants at 20[o]C. No rescue is seen when only one copy of the transgene is used.

Expression of Cg25C^hs.9.7 is unable to suppress the recessive lethality seen in vkg^sz-14/vkg^b-14 mutants at 20[o]C. No rescue is seen when only one copy of the transgene is used.

Expression of Cg25C^hs.9.7 is unable to suppress the recessive lethality seen in vkg^b-14/vkg^b-35 mutants at 20[o]C. No rescue is seen when only one copy of the transgene is used.

(Kelemen-Valkony et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Col4a1^hs.9.7 partially rescues Col4a1^a-30

(Kelemen-Valkony et al., 2012)

Col4a1^hs.9.7 partially rescues Col4a1^h-13/Col4a1^b-9

(Kelemen-Valkony et al., 2012)

Col4a1^hs.9.7 partially rescues Col4a1^DTS-L2

(Kelemen-Valkony et al., 2012)

Col4a1^hs.9.7 partially rescues Col4a1^b-29/Col4a1^b-9

(Kelemen-Valkony et al., 2012)

Col4a1^hs.9.7 partially rescues Col4a1^DTS-L3

(Kelemen-Valkony et al., 2012)

Comments

Expression of Cg25C^hs.9.7 partially rescues the dominant semi-lethality seen in Cg25C^DTS-L3/+ mutants at 29[o]C.

Expression of Cg25C^hs.9.7 partially rescues the dominant semi-lethality seen in Cg25C^DTS-L2/+ mutants at 29[o]C.

Expression of Cg25C^hs.9.7 partially rescues the dominant semi-lethality seen in Cg25C^a-30/+ mutants at 29[o]C.

Expression of two copies of Cg25C^hs.9.7 partially rescues the recessive lethality seen in Cg25C^b-9/Cg25C^b-29 mutants at 20[o]C. No rescue is seen when only one copy of the transgene is used.

Expression of two copies of Cg25C^hs.9.7 partially rescues the recessive lethality seen in Cg25C^b-9/Cg25C^h-13 mutants at 20[o]C. No rescue is seen when only one copy of the transgene is used.

(Kelemen-Valkony et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cg25C^hs.9.7

Col4a1^hs.9.7

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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