FlyBase Allele Report: Dmel\Ehbp1[A28]

General Information

Symbol

Dmel\Ehbp1^A28

Species

D. melanogaster

Name

FlyBase ID

FBal0267628

Feature type

allele

Associated gene

Dmel\Ehbp1

Associated Insertion(s)

Carried in Construct

Also Known As

dEHBP1^A28

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutation in a splice acceptor site (AG to AA).

(Giagtzoglou et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:17,013,482..17,013,482 [-]

Nucleotide change:

G17013482A

Comment:

AG to AA mutation in the splice acceptor for the 4th intron of Ehbp1-RB.

(Giagtzoglou et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of first instar larval stage (with Df(2R)Exel6065)

(Giagtzoglou et al., 2012)

lethal - all die before end of first instar larval stage (with Ehbp1^O4)

(Giagtzoglou et al., 2012)

lethal - all die before end of first instar larval stage (with Ehbp1^ΔEx24)

(Giagtzoglou et al., 2012)

lethal - all die before end of larval stage (with Ehbp1^k09837)

(Giagtzoglou et al., 2012)

lethal - all die before end of larval stage (with Ehbp1^T14)

(Giagtzoglou et al., 2012)

lethal - all die before end of second instar larval stage (with Ehbp1^N8)

(Giagtzoglou et al., 2012)

some die during first instar larval stage (with Df(2R)Exel6065)

(Giagtzoglou et al., 2012)

some die during first instar larval stage (with Ehbp1^O4)

(Giagtzoglou et al., 2012)

some die during first instar larval stage (with Ehbp1^ΔEx24)

(Giagtzoglou et al., 2012)

some die during second instar larval stage (with Ehbp1^N8)

(Giagtzoglou et al., 2012)

some die during third instar larval stage (with Ehbp1^k09837)

(Giagtzoglou et al., 2012)

some die during third instar larval stage (with Ehbp1^T14)

(Giagtzoglou et al., 2012)

visible | somatic clone

(Giagtzoglou et al., 2012)

Phenotype Manifest In

chaeta | somatic clone

(Giagtzoglou et al., 2012)

Detailed Description

Statement

Reference

Homozygous clones on the adult thorax bear no bristles.

(Giagtzoglou et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Ehbp1^k09837

(Giagtzoglou et al., 2012)

Rescued by

Ehbp1^k09837/Ehbp1^A28 is rescued by Ehbp1^+t9.1

(Giagtzoglou et al., 2012)

Df(2R)Exel6065/Ehbp1^A28 is rescued by Ehbp1^+t9.1

(Giagtzoglou et al., 2012)

Df(2R)Exel6065/Ehbp1^A28 is rescued by Ehbp1^UAS.Tag:FLAG/Scer\GAL4^αTub84B.PL

(Giagtzoglou et al., 2012)

Ehbp1^A28/Ehbp1^O4 is rescued by Ehbp1^+t9.1

(Giagtzoglou et al., 2012)

Ehbp1^A28/Ehbp1^N8 is rescued by Ehbp1^+t9.1

(Giagtzoglou et al., 2012)

Ehbp1^A28/Ehbp1^T14 is rescued by Ehbp1^+t9.1

(Giagtzoglou et al., 2012)

Ehbp1^ΔEx24/Ehbp1^A28 is rescued by Ehbp1^+t9.1

(Giagtzoglou et al., 2012)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

67144

y¹ w^*; P{neoFRT}42D Ehbp1^A28/CyO

Notes on Origin

Discoverer

Animals homozygous for the Ehbp1^A28 chromosome show first instar lethality, which is not rescued by Ehbp1^+t9.1. The lethality of the Ehbp1^A28 chromosome in combination with other Ehbp1 mutations is rescued by Ehbp1^+t9.1, suggesting that the Ehbp1^A28 chromosome may carry a second-site lethal mutation.

(Giagtzoglou et al., 2012)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

A28

(Giagtzoglou et al., 2012)

Ehbp1^A28

(Gao et al., 2024, Nakamura et al., 2020)

dEHBP1^A28

(Giagtzoglou et al., 2013, Giagtzoglou et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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