FB2026_02 , released June 18, 2026
Allele: Dmel\MtpβKO
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General Information
Symbol
Dmel\MtpβKO
Species
D. melanogaster
Name
FlyBase ID
FBal0267654
Feature type
allele
Associated gene
Dmel\Mtpβ
Associated Insertion(s)
TI{TI}MtpβKO
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Kishita et al., 2012)
Progenitor genotype
Associated Insertion(s)
TI{TI}MtpβKO
Cytology
Description

Sequence encoding the Thiolase thiolase active site has been replaced by a w+* marker.

(Kishita et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:23,867,247..23,868,525 [-]
Comment:

Part of Mtpβ has been replaced by a w+* marker. The position of the deletion endpoints on the reference sequence was inferred from the reported primer sequences used to generate the homology arms.

(Kishita et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  steatotic liver disease
      CEA
      (Kishita et al., 2012)
      model of  lipid metabolism disorder
      CEA
      (Kishita et al., 2012)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MtpβKO homozygous larvae exhibit a large progenitor pool at the expense of differentiated cells in the lymph gland primary lobe.

      (Tiwari et al., 2020)

      The mean lifespan of mutant male flies (45.8 +/- 1.0 days) is significantly shorter than that of control males (52.1 +/- 1.5 days).

      Mutant adults show significantly slower climbing ability than control flies at 10 and 20 days after eclosion.

      Mutant females lay approximately 20% fewer eggs compared to wild type.

      Mutant adults do not show a significant difference in starvation resistance compared to wild-type controls.

      Fat body cells of fed mutant flies contain larger lipid droplets compared to cells from wild-type control flies and the mutant flies have higher overall triacylglyceride levels than wild type. The size of the lipid droplets, and the overall triacylglyceride levels are reduced by starvation in the mutant flies, as occurs in wild type.

      (Kishita et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MtpβKO
      (Wessel and Drummond-Barbosa, 2026, Tiwari et al., 2020, Kishita et al., 2012)
      ThiolaseKO
      Name Synonyms
      Secondary FlyBase IDs
        References (3)