FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\FUSUAS.cMa.Tag:HA
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General Information
Symbol
Hsap\FUSUAS.cMa.Tag:HA
Species
H. sapiens
Name
FlyBase ID
FBal0267915
Feature type
allele
Associated gene
Hsap\FUS
Associated Insertion(s)
Carried in Construct
M{UAS-hFUS.M}
Also Known As
UAS-FUS
Key Links
Transgenic product class
cDNA
(Miguel et al., 2012)
wild_type
(Miguel et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Miguel et al., 2012)
wild_type
(Miguel et al., 2012)
Mutagen
in vitro construct
(Miguel et al., 2012)
Progenitor genotype
Carried in construct
M{UAS-hFUS.M}
Cytology
Description

UAS regulatory sequences drive expression of a Hsap\FUS cDNA which is tagged at the N-terminal end with Tag:HA.

(Miguel et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\FUS
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  frontotemporal dementia
      is ameliorated by Hsap\HSPA1LUAS.cWa
      (Miguel et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF at 25[o]C results in a very weak abnormal eye phenotype on eclosion, with a defect in the formation of interommatidial bristles. When expressed at 29[o]C, there is a more severe disruption in eye morphology, with a larger number of malformed interommatidial bristles and the appearance of numerous ectopic cell extensions.

      Expression of Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 under the control of Scer\GAL4elav.Switch.PO results in a decrease in mean lifespan compared to controls, with the decrease becoming more severe in a dose-dependent manner with increasing concentrations of RU486.

      (Miguel et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\HSPA1LScer\UAS.cWa strongly suppresses the eye defects caused by expression of Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF at 29[o]C.

      Co-expression of Hsap\HSPA1LScer\UAS.cWa strongly suppresses the decrease in lifespan caused by expression of Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 under the control of Scer\GAL4elav.Switch.PO in the presence of RU486.

      (Miguel et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\FUSScer\UAS.cMa.T:Ivir\HA1
      Hsap\FUSUAS.cMa.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (5)