FB2026_02 , released June 18, 2026
Allele: Dmel\Apc2FL.EGFP
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General Information
Symbol
Dmel\Apc2FL.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0268076
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
P{Apc2-EGFP.FL}
Also Known As
APC2-FL, P[endoP-EGFP-APC2-FL]
Key Links
Transgenic product class
wild_type
(Zhou et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Zhou et al., 2011)
Mutagen
in vitro construct
(Zhou et al., 2011)
Progenitor genotype
Carried in construct
P{Apc2-EGFP.FL}
Cytology
Description

EGFP tagged full length Apc2 is expressed under the control of the native promoter.

(Zhou et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Apc2
Encoded product / tool
Apc2
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Apc2FL.T:Avic\GFP-EGFP partially suppresses the lethality seen in embryos derived from females carrying homozygous Apc2g10 ApcQ8 germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 46% of embryos are able to hatch. The remaining progeny exhibit a very weak cuticle phenotype.

      (Kunttas-Tatli et al., 2012)

      Expression of Apc2FL.T:Avic\GFP-EGFP suppresses the lethality seen in embryos derived from females carrying homozygous Apc2g10 ApcQ8 germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 46% of embryos are able to hatch. The cuticle defects are also significantly rescued.

      (Zhou et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Apc2FL.EGFP rescues Apc2g10

      (Kunttas-Tatli et al., 2012)
      Partially rescues

      Apc2FL.EGFP partially rescues Apc2g10

      (Zhou et al., 2011)
      Comments

      Expression of Apc2FL.T:Avic\GFP-EGFP completely rescues the lethality seen in embryos that are both maternally and zygotically mutant for Apc2g10, resulting in a 98% hatch rate. Very weak cuticle defects are seen in the few embryos that fail to hatch.

      (Kunttas-Tatli et al., 2012)

      Expression of Apc2FL.T:Avic\GFP-EGFP completely rescues the lethality seen in embryos that are both maternally and zygotically mutant for Apc2g10, resulting in a 96% hatch rate and a viable, fertile stock.

      Expression of Apc2FL.T:Avic\GFP-EGFP significantly rescues the pseudocleavage furrow extension defects seen in embryos that are both maternally and zygotically mutant for Apc2g10 (generated using the FRT-FLP-DFS technique). 7% of cortical actin rings in the four cortical divisions before cellularisation are incomplete.

      (Zhou et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Apc2FL.EGFP
      Apc2FL.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (5)