FlyBase Allele Report: Dmel\Dcr-1[18E6]

General Information

Symbol

Dmel\Dcr-1^18E6

Species

D. melanogaster

Name

FlyBase ID

FBal0268182

Feature type

allele

Associated gene

Dmel\Dcr-1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Smibert et al., 2011)

Progenitor genotype

Cytology

Description

Amino acid replacement: A2227V.

(Smibert et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:22,734,179..22,734,179 [-]

Nucleotide change:

C22734179T

Amino acid change:

A2227V | Dcr-1-PA

Reported amino acid change:

A2227V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Smibert et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage | somatic clone

(Smibert et al., 2011)

lethal - all die before end of P-stage (with Dcr-1^Q1147X)

(Smibert et al., 2011)

some die during pharate adult stage (with Dcr-1^Q1147X)

(Smibert et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Dcr-1^18E6/Dcr-1^Q1147X results in pharate adults with normal morphology, although some adult escapers are seen.

Flies containing whole eye homozygous clones show a significant reduction of the "on" transient of the electroretinogram compared to wild-type flies.

(Smibert et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dcr-1^18E6 is a suppressor | partially | somatic clone of abnormal eye color phenotype of w^{RNAi.GUS.DsRed(T4)}

(Smibert et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dcr-1^18E6 is a suppressor | partially | somatic clone of eye phenotype of w^{RNAi.GUS.DsRed(T4)}

(Smibert et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dcr-1^18E6

dcr-1^18E6

(Smibert et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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