FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\garzR1044
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General Information
Symbol
Dmel\garzR1044
Species
D. melanogaster
Name
FlyBase ID
FBal0268289
Feature type
allele
Associated gene
Dmel\garz
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Armbruster and Luschnig, 2012)
Progenitor genotype
Cytology
Description

(Coordinates refer to the position of the lesion in the garz-RB cDNA).

(Armbruster and Luschnig, 2012)

Nucleotide substitution: C3130T.

(Armbruster and Luschnig, 2012)

Amino acid replacement: R1044term.

(Armbruster and Luschnig, 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:12,330,175..12,330,175 [+]
Nucleotide change:

C12330175T

Reported nucleotide change:

C3130T

Amino acid change:

R1044term | garz-PA; R1044term | garz-PB; R1044term | garz-PC

Reported amino acid change:

R1044term

(Armbruster and Luschnig, 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early tracheal development is normal in mutant embryos, but the lumen of the dorsal tracheal trunk fails to expand to its normal diameter and tracheal tubes do not fill with gas in stage 16 mutant embryos. The cuticle is weakly pigmented and appears transparent.

      Stage 16 garzR1044/Df(2R)Exel6061 embryos have narrow tracheal and salivary gland lumens.

      (Armbruster and Luschnig, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\GBF1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4btl.PS rescues the narrow diameter of the tracheal dorsal trunk lumen which is seen in garzR1044/Df(2R)Exel6061 embryos.

      (Armbruster and Luschnig, 2012)
      Complementation and Rescue Data
      Fails to complement

      garzEP2028

      (Armbruster and Luschnig, 2012)
      Rescued by

      Df(2R)Exel6061/garzR1044 is rescued by Scer\GAL4btl.PS/garzUAS.B

      (Armbruster and Luschnig, 2012)
      Comments

      Expression of garzScer\UAS.B under the control of Scer\GAL4btl.PS rescues the narrow diameter of the tracheal dorsal trunk lumen which is seen in garzR1044/Df(2R)Exel6061 embryos.

      (Armbruster and Luschnig, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      agaR1044
      (Armbruster and Luschnig, 2012)
      garzR1044
      (Armbruster and Luschnig, 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)