FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dcr-138E3
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General Information
Symbol
Dmel\Dcr-138E3
Species
D. melanogaster
Name
FlyBase ID
FBal0268326
Feature type
allele
Associated gene
Dmel\Dcr-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: K1455?.

    (Azzam et al., 2012)

    Mutation resulting in a frameshift at residue K1455, producing two amino acids (HI) following by a stop codon.

    (Azzam et al., 2012)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3R:22,736,549..22,736,550 [-]
    Comment:

    A frameshift after K1457 leads to production of two out of frame amino acids (HI) followed by a premature stop. Curator note: The frameshift event was not specified but it appears to be the removal of two bases (CC).

    (Azzam et al., 2012)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        7 days old females carrying homozygous germline clones result in egg chambers with 8 nurse cells and no oocyte with 63% penetrance.

        (Azzam et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Dcr-138E3 is a suppressor | partially | somatic clone of abnormal eye color phenotype of wRNAi.GUS.DsRed(T4)

        (Azzam et al., 2012)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        Dcr-138E3 is a suppressor | partially | somatic clone of eye phenotype of wRNAi.GUS.DsRed(T4)

        (Azzam et al., 2012)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Dcr-138E3
        dcr-138E3
        (Azzam et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)