FB2026_02 , released June 18, 2026
Allele: Dmel\Mef2RNAi.2.UAS
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General Information
Symbol
Dmel\Mef2RNAi.2.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0268405
Feature type
allele
Associated gene
Dmel\Mef2
Associated Insertion(s)
Carried in Construct
P{UAS-Mef2.RNAi.2}
Key Links
Transgenic product class
RNAi_reagent
(Bryantsev et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Bryantsev et al., 2012)
Mutagen
in vitro construct
(Bryantsev et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Mef2.RNAi.2}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of approximately 700bp of Mef2 coding sequence in tail-to-tail orientation.

(Bryantsev et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mef2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL41151 singGD3396 pharate adults show a myoblast fusion defect at the stage following the formation of F-actin foci.

      (Brunetti et al., 2015)

      Animals expressing Mef2dsRNA.IR2.Scer\UAS under the control of Scer\GAL41151 develop normally but remain in their pupal cases and eventually die, unable to eclose. The animals lack essentially all major somatic muscles in their bodies. In the thorax, only a few escaper muscles and some miniature muscles remain, while in the abdomen, virtually all the transverse and longitudinal muscles are absent. Myoblast fusion is stalled in these animals.

      The wavy morphology of the dorso-ventral muscle myofibrils of pupae expressing Mef2GD5039 under the control of Scer\GAL4Act88F.PB is worsened if the animals also carry Mef2dsRNA.IR2.Scer\UAS.

      Expression of Mef2dsRNA.IR2.Scer\UAS under the control of Scer\GAL4Act79B.PB results in changes in morphology in the tergal depressor of the trochanter muscle, including disorganised myofibrils, misshapen fibres and a reduction in overall muscle size.

      Expression of Mef2dsRNA.IR2.Scer\UAS under the control of Scer\GAL4Act88F.PB results in collapsed dorsal longitudinal muscles and disorganised myofibrils.

      Flies expressing Mef2dsRNA.IR2.Scer\UAS under the control of Scer\GAL4EDTP-DJ694 at 29[o]C have a shortened lifespan.

      (Bryantsev et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Mef2RNAi.2.UAS
      Mef2RNAi.IR2.UAS
      Mef2dsRNA.IR2.Scer\UAS
      Mef2dsRNA.IR2.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)