FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PolH12
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General Information
Symbol
Dmel\PolH12
Species
D. melanogaster
Name
FlyBase ID
FBal0268416
Feature type
allele
Associated gene
Dmel\PolH
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kane et al., 2012)
Progenitor genotype
Cytology
Description

Imprecise excision of an insertion in DNApol-η, resulting in a deletion of part of the coding region.

(Kane et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant larvae exposed to UV radiation show reduced survival to adulthood compared to controls.

      (Delabaere et al., 2014)

      Mutant larvae are severely sensitive to ultraviolet radiation, but are not sensitive to nitrogen mustard or to ionising radiation.

      Mutants show a 45% decrease in full homologous recombination (HR) repair events in assays of excision and repair events of P{hswa}, but the frequency of aborted HR is unchanged. Analysis of aborted HR products shows no significant difference in the synthesis tract lengths between repair events isolated from mutant or wild-type flies.

      (Kane et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      PolH12, Rev1ΔCTD has chemical sensitive phenotype

      (Khodaverdian et al., 2024)

      PolH12, Rev1ΔCTD has increased mortality | chemical conditional phenotype

      (Khodaverdian et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      DNApol-η12 mus2053B double mutants show no difference in the frequency of full homologous recombination (HR) repair events in assays of excision and repair events of P{hswa} compared to wild type. The repair tract lengths in aborted HR products isolated from the double mutants are substantially increased compared to wild type.

      Pol32L2 DNApol-η12 double mutants show a 60% decrease in full HR repair events in assays of excision and repair events of P{hswa}, but repair synthesis tract lengths of aborted HR products are increased dramatically over wild type.

      (Kane et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      DNApol-eta12
      (Delabaere et al., 2014)
      DNApol-η12
      PolH12
      pol eta12
      (Khodaverdian et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)