FB2026_02 , released June 18, 2026
Allele: Dmel\mei-P22CA1215
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General Information
Symbol
Dmel\mei-P22CA1215
Species
D. melanogaster
Name
FlyBase ID
FBal0268458
Feature type
allele
Associated gene
Dmel\mei-P22
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ferguson et al., 2012)
Progenitor genotype
Cytology
Description

Missense mutation (R31C) and a 36bp deletion that removes amino acid residues 67-78.

(Ferguson et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:7,244,586..7,244,621 [+]
Comment:

A 36bp deletion that removes amino acid residues 67-78. One of two lesions in mutant.

(Ferguson et al., 2012)
point_mutation
3L:7,244,478..7,244,478 [+]
Nucleotide change:

C7244478T

Amino acid change:

R31C | mei-P22-PA

Reported amino acid change:

R31C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of two lesions in mutant.

(Ferguson et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      mei-P22CA1215 is a suppressor of dorsal appendage | maternal effect phenotype of spn-BBU

      (Ferguson et al., 2012)

      mei-P22CA1215 is a suppressor of karyosome phenotype of spn-BBU

      (Ferguson et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ventralisation phenotype seen in eggs laid by spn-BBU females is suppressed if the females are also mutant for mei-P22CA1215.

      The failure of karyosome condensation which is seen in spn-BBU oocytes is suppressed by mei-P22CA1215.

      (Ferguson et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mei-P22CA1215
      (Ferguson et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)