FlyBase Allele Report: Dmel\Pkc53E[EY14093]

General Information

Symbol

Dmel\Pkc53E^EY14093

Species

D. melanogaster

Name

FlyBase ID

FBal0268609

Feature type

allele

Associated gene

Dmel\Pkc53E

Associated Insertion(s)

P{EPgy2}Pkc53E^EY14093

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Murillo-Maldonado et al., 2011)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Pkc53E^EY14093

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,924,500..16,924,500 [+]

(Murillo-Maldonado et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage | dominant

(Murillo-Maldonado et al., 2011)

fertile

(Murillo-Maldonado et al., 2011)

viable

(Murillo-Maldonado et al., 2011)

Phenotype Manifest In

wing blade

(Murillo-Maldonado et al., 2011)

wing vein | ectopic

(Murillo-Maldonado et al., 2011)

Detailed Description

Statement

Reference

Wing blade area is reduced by 11.5% in homozygous Pkc53E^EY14093 mutant males compared to wild type. Approximately 50% of flies show ectopic wing veins. Flies homozygous for Pkc53E^EY14093 show <1% of ommatidia with extra R7 photoreceptor cells

(Murillo-Maldonado et al., 2011)

One copy of Pkc53E^EY14093 has no effect on hemocyte proliferation in third instar larvae.

(Sinenko et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Pkc53E[+]/Pkc53E^EY14093 is an enhancer of abnormal size | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Pkc53E[+]/Pkc53E^EY14093 is an enhancer of increased cell number | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Pkc53E[+]/Pkc53E^EY14093 is an enhancer of increased cell number | third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

Pkc53E[+]/Pkc53E^EY14093 is an enhancer of wing blade phenotype of sl²

(Murillo-Maldonado et al., 2011)

Pkc53E[+]/Pkc53E^EY14093 is an enhancer of wing vein | ectopic phenotype of sl²

(Murillo-Maldonado et al., 2011)

Pkc53E[+]/Pkc53E^EY14093 is an enhancer of photoreceptor cell R7 | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Pkc53E[+]/Pkc53E^EY14093 is an enhancer of embryonic/larval hemocyte | third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Pkc53E^EY14093 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of Pkc53E^EY14093 significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Pkc53E^EY14093 enhances the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

(Murillo-Maldonado et al., 2011)

Xenogenetic Interactions

Statement

Reference

One copy of Pkc53E^EY14093 moderately enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

(Sinenko et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

20790

y¹ w^67c23; P{EPgy2}Pkc53E^EY14093/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PKC53E^EY14093

(Murillo-Maldonado et al., 2011)

Pkc53E^EY14093

(Vrailas-Mortimer et al., 2021, Sinenko et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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