FlyBase Allele Report: Dmel\Archease[dsj-169]

General Information

Symbol

Dmel\Archease^dsj-169

Species

D. melanogaster

Name

FlyBase ID

FBal0268635

Feature type

allele

Associated gene

Dmel\Archease

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ghabrial et al., 2011)

Progenitor genotype

Cytology

Description

Amino acid replacement: G115E.

(Francis et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:21,661,956..21,661,956 [-]

Nucleotide change:

G21661956A

Amino acid change:

G115E | Archease-PA

Reported amino acid change:

G115E

Comment:

Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Francis et al., 2022)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of second instar larval stage

(Francis et al., 2022)

Phenotype Manifest In

adherens junction | increased number | larval stage

(Francis et al., 2022)

eye | somatic clone

(Ghabrial et al., 2011)

larval tracheal system

(Ghabrial et al., 2011)

terminal tracheal cell

(Ghabrial et al., 2011)

terminal tracheal cell | larval stage | somatic clone

(Francis et al., 2022)

Detailed Description

Statement

Reference

disjointed¹⁶⁹ mutant tracheal terminal cells exhibit an autocellular-seamless tube junction gas-filling defect. There is mild to moderate pruning.

(Ghabrial et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Archease^dsj-169 has terminal tracheal cell | somatic clone | larval stage phenotype, non-suppressible by Rheb^UAS.cPa/Scer\GAL4^btl.PS

(Francis et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Archease^dsj-169 is rescued by Scer\GAL4^btl.PS/Archease^UAS.Tag:HA

(Francis et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

63091

w^*; P{GAL4-btl.S}2, P{UASp-Act5C.T:GFP}2; P{FRT(w^hs)}2A P{neoFRT}82B Archease^dsj-169/TM3, P{tubP-GAL80}3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

169

(Ghabrial et al., 2011)

Archease^dsj-169

disjointed¹⁶⁹

dsj¹⁶⁹

(Francis et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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