FlyBase Allele Report: Dmel\mgr[5]

General Information

Symbol

Dmel\mgr⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0268991

Feature type

allele

Associated gene

Dmel\mgr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

mgr⁵ harbors a nonsense mutation in mgr, producing a truncated protein, and additionally carries a 41-bp deletion in the mgr 3' UTR.

(Delgehyr et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle (with mgr^l4)

(Delgehyr et al., 2012)

abnormal mitotic cell cycle (with mgr^l4)

(Delgehyr et al., 2012)

lethal | pharate adult stage (with mgr^l4)

(Delgehyr et al., 2012)

partially lethal - majority die | pharate adult stage (with mgr^l4)

(Delgehyr et al., 2012)

sterile (with mgr^l4)

(Delgehyr et al., 2012)

Phenotype Manifest In

larval neuroblast (with mgr^l4)

(Delgehyr et al., 2012)

mature primary spermatocyte cyst cell (with mgr^l4)

(Delgehyr et al., 2012)

meiotic spindle (with mgr^l4)

(Delgehyr et al., 2012)

microtubule (with mgr^l4)

(Delgehyr et al., 2012)

mitotic spindle (with mgr^l4)

(Delgehyr et al., 2012)

Detailed Description

Statement

Reference

mgr^l4/mgr⁵ neuroblasts from third instar larval brains exhibit circular mitotic figures; spindles may be monopolar or bipolar with abnormal morphology. Their mitotic index and the ratio of metaphase:anaphase figures is elevated some twofold over that of wild type, and they show increased defective and monopolar mitoses. These data indicate a delay in progression through the mitotic cycle.

mgr^l4/mgr⁵ animals show pharate lethality with some sterile adults.

mgr^l4/mgr⁵ testes cells can undergo the premeiotic mitosis. However, meiotic spindles are either absent or highly abnormal in mature (but not young) primary spermatocyte cysts.

mgr^l4/mgr⁵ larval brain squashes show a slight loss of microtubules.

(Delgehyr et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

mgr^l4/mgr⁵ has microtubule phenotype, enhanceable by βTub56D^GFP

(Delgehyr et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mgr⁵

(Delgehyr et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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