FB2026_02 , released June 18, 2026
Allele: Dmel\Toll-7g1-5
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General Information
Symbol
Dmel\Toll-7g1-5
Species
D. melanogaster
Name
FlyBase ID
FBal0269083
Feature type
allele
Associated gene
Dmel\Toll-7
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
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        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Compared with wild-type, Toll-7g1-5/Df(2R)BSC22 mutant flies exhibit diminished survival and elevated viral titers after infection with Rift Valley Fever Virus (RVFV). Infection with either Drosophila C virus (DCV), Flockhouse virus (FHV), or Sindbis virus (SINV) results in no change in survival of the mutants relative to controls. Rapamycin treatment of the mutants reduced viral RNA to amounts similar to those detected in control flies.

        (Moy et al., 2014)

        Toll-7g1-5/Df(2R)BSC22 flies that have been challenged with vesicular stomatitis virus (VSV) show significantly increased levels of viral replication compared to that seen in wild-type controls. The flies show reduced survival compared to control flies after infection with VSV.

        (Nakamoto et al., 2012)
        External Data
        Interactions
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        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Toll-7g1-5
        (Zhang et al., 2024, Moy et al., 2014, Nakamoto et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)