FB2026_02 , released June 18, 2026
Allele: Dmel\egrΔ25
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General Information
Symbol
Dmel\egrΔ25
Species
D. melanogaster
Name
FlyBase ID
FBal0269192
Feature type
allele
Associated gene
Dmel\egr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Keller et al., 2011)
Mutagen
Delta2-3 transposase
(Keller et al., 2011)
Progenitor genotype
Cytology
Description

An approximately 1.5kb genomic region including the predicted transcriptional and translational start sites and first exon of egr has been deleted through P-element excision.

(Keller et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      egrΔ25 mutant third instar larvae display normal NMJ morphology and wild type apposition of pre-and postsynaptic markers. The number of boutons does not differ significantly from wild type animals.

      Average EPSPs in homozygous egrΔ25 mutants are statistically similar to wild-type.

      (Keller et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      egrΔ25 is a suppressor | partially of abnormal neuroanatomy phenotype of Ank2f02001

      (Keller et al., 2011)

      egrΔ25 is a suppressor | partially of abnormal neurophysiology phenotype of Ank2f02001

      (Keller et al., 2011)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      egrΔ25 is a non-suppressor of microtubule | third instar larval stage phenotype of Ank2f02001

      (Keller et al., 2011)

      egrΔ25 is a non-suppressor of axon | third instar larval stage phenotype of Ank2f02001

      (Keller et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      egrΔ25 partially suppresses the NMJ degeneration seen in Ank2f02001 mutant third instar larvae. The axonal blockages and microtubule disruption are not suppressed.

      egrΔ25 partially suppresses the synaptic transmission defects seen in Ank2f02001 mutants. A near complete rescue in the number of small EPSPs is seen, however average EPSP amplitude is not completely restored to wild type levels.

      (Keller et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EgrΔ25
      (Wang et al., 2020)
      egrΔ25
      Name Synonyms
      Secondary FlyBase IDs
        References (2)