FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mhc15b
Open Close
General Information
Symbol
Dmel\Mhc15b
Species
D. melanogaster
Name
FlyBase ID
FBal0269228
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
P{Mhc.15b}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Suggs et al., 2007)
Progenitor genotype
Carried in construct
P{Mhc.15b}
Cytology
Description

Mhc genomic DNA in which exons 15a and 15b and their flanking introns are replaced with cDNA containing exons 14, 15b and 16 resulting in the expression of an isovariant containing slow muscle hinge B in place of the fast muscle isovariant hinge A in the Mhc isoforms of indirect flight and jump muscles.

(Suggs et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
Mhc
Encoded product / tool
Mhc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Compared with wild-type, the flight ability of Mhc10 mutants expressing Mhc15b is impaired. The flight ability of these flies declines more rapidly with age than that of controls.

      Compared with controls, Mhc10 mutant flies expressing Mhc15b display a reduced ability to jump.

      Electrophysiological responses of flight muscles in Mhc10 mutants expressing Mhc15b appear normal.

      Expression of Mhc15b in Mhc10 mutants results in myofibrils with generally wild-type structure. However, there are a variety of minor defects not observed in the control line including myofibrils with disrupted M lines and rough edges. The frequency and severity of defects vary among different insertion lines. Myofibril dimensions of Mhc10 mutants expressing Mhc15b differ from that of wild-type. The myofibril defects appear use-dependent as they are less frequent and less severe in newly eclosed flies than in older adults.

      (Suggs et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Mhc15b fails to rescue Mhc10

      (Suggs et al., 2007)
      Comments

      Compared with wild-type, the flight ability of Mhc10 mutants expressing Mhc15b is impaired. The flight ability of these flies declines more rapidly with age than that of controls.

      Compared with controls, Mhc10 mutant flies expressing Mhc15b display a reduced ability to jump.

      (Suggs et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mhc15b
      Name Synonyms
      Secondary FlyBase IDs
        References (1)