FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MhcEMB-7d
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General Information
Symbol
Dmel\MhcEMB-7d
Species
D. melanogaster
Name
FlyBase ID
FBal0269230
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
P{MHC.EMB-7d}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Miller et al., 2005)
Progenitor genotype
Carried in construct
P{MHC.EMB-7d}
Cytology
Description

An altered genomic fragment expressing an embryonic body wall muscle Mhc isovariant with indirect flight muscle alternative exon 7d replacing embryonic alternative exon 7a.

(Miller et al., 2005)
Allele components
Component
Use(s)
Encoded product / tool
Mhc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MhcEMB-7d in Mhc10 mutants allows normal myofibrillar assembly evidenced at 2 hours post-eclosion. By two days indirect flight muscle myofilaments do show some disruption.

      Transgenic Mhc10 mutant flies expressing MhcEMB-7d show impairment in jump ability and they are not able to fly.

      (Miller et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      MhcEMB-7d fails to rescue Mhc10

      (Miller et al., 2005)
      Comments

      Expression of MhcEMB-7d in Mhc10 mutants allows normal myofibrillar assembly evidenced at 2 hours post-eclosion. By two days indirect flight muscle myofilaments do show some disruption.

      Transgenic Mhc10 mutant flies expressing MhcEMB-7d show impairment in jump ability and they are not able to fly.

      (Miller et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MhcEMB-7d
      Name Synonyms
      Secondary FlyBase IDs
        References (1)